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Be Part of Research - Trial Details - A Study of Samuraciclib and Elacestrant in Participants with Metastatic or Locally Advanced HR+/HER2-negative Breast Cancer

A Study of Samuraciclib and Elacestrant in Participants with Metastatic or Locally Advanced HR+/HER2-negative Breast Cancer

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Breast Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is an international, multisite, open-label, Phase 1b/2 study, to confirm safety and efficacy of samuraciclib in combination with elacestrant in adult participants with metastatic or locally advanced Hormone Receptor (HR) positive and Human Epidermal Growth Factor Receptor (HER)2-negative breast cancer.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Oct 2023 Dec 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Samuraciclib capsules by mouth once a day

Intervention Arm Group : Cohort 1;Cohort 2;Cohort 3;Cohort 4 Expansion;

Intervention Type : DRUG
Intervention Description : Elacestrant tablets by mouth once a day

Intervention Arm Group : Cohort 1;Cohort 2;Cohort 3;Cohort 4 Expansion;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Site 12 - Belfast City Hospital
    Belfast
  • Site 4 - The Christie NHS Foundation Trust
    Manchester
  • Site 2 - Oxford University Hospitals NHS Trust - Churchill Hospital
    Oxford
    OX3 7LE


The study is sponsored by Carrick Therapeutics Limited and is in collaboration with Berlin-Chemie AG Menarini Group.




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Read full details for Trial ID: NCT05963997
Last updated 20 February 2025

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