Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Daniel Griffiths 02381205154
decipher@soton.ac.uk


Elizabeth Smyth 023 81205773
elizabeth.smyth2@nhs.net


Study Location:

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Be Part of Research - Trial Details - Developing ctDNA Guided Adjuvant Therapy for Gastrooesophageal Cancer

Developing ctDNA Guided Adjuvant Therapy for Gastrooesophageal Cancer

Medical Conditions


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Multicentre, single arm, open label UK phase II trial to assess the efficacy of trastuzumab deruxtecan in reducing micrometastatic disease burden in HER2 positive GOA patients who are ctDNA positive after chemotherapy and surgery. 25 patients will be recruited from approximately 15 NHS secondary care sites.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Apr 2024 Mar 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Trastuzumab deruxtecan is an antibody-drug conjugate that contains trastuzumab covalently linked to deruxtecan, a topoisomerase I inhibitor. It is given by intravenous infusion.

Intervention Arm Group : Trastuzumab deruxtecan;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Oxford University Hospitals NHS Trust, Churchill Hospital
    Oxford
    OX3 7LE
  • University Hospital Southampton NHS Foundation Trust, Southampton General Hospital
    Southampton
    Hampshire
    SO16 6YD
  • Royal Surrey NHS Foundation Trust, Royal Surrey County Hospital
    Guildford
    Surrey
    GU2 7XX
  • University Hospitals Coventry and Warwickshire, University Hospital Coventry
    Coventry
    Warwickshire
    CV2 2DX
  • Belfast Health and Social Care Trust, Belfast City Hospital
    Belfast
    BT9 7AB
  • Cambridge University Hospital NHS Foundation Trust, Addenbrookes Hospital
    Cambridge
    CB2 0QQ
  • University Hospitals of Derby and Burton NHS Foundation Trust, Royal Derby Hospital
    Derby
    DE22 3NE
  • NHS Tayside, Ninewells Hospital
    Dundee
    DD2 1UB
  • Hull University Teaching Hospitals NHS Trust, Castel Hill Hospital
    Hull
    HU16 5JQ
  • Leeds Teaching Hospitals NHS Trust, St James's University Hospital
    Leeds
    LS9 7TF
  • University College London Hospitals NHS Foundation Trust, University College Hospital London
    London
    NW1 2BU
  • Guys & St Thomas NHS Foundation Trust, Guy's Hospital
    London
    SE1 9RT
  • Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk and Norwich University Hospital
    Norwich
    NR4 7UY
  • Lancashire Teaching Hospitals NHS Foundation Trust, Royal Preston Hospital
    Preston
    PR2 9HT
  • Velindre University NHS Trust, Velindre Cancer Centre
    Whitchurch
    CF14 2TL
  • The Christie NHS Foundation Trust
    Manchester
    M20 4BX


The study is sponsored by University of Southampton and is in collaboration with AstraZeneca; Natera, Inc..





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Read full details for Trial ID: NCT05965479
Last updated 25 June 2024

This page is to help you find out about a research study and if you may be able to take part

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