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Contact Information:

George Naumov, PhD
(617) 835-5633
MITOPE@rsoncology.com


Study Location:

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Be Part of Research - Trial Details - Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma

Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma

Recruiting

Open to: All Genders

Age: 18 Years - N/A

Medical Conditions

Malignant Pleural Effusion
Malignant Pleural Mesothelioma
Mesothelioma
Mesotheliomas Pleural
Mesothelioma
Lung
Pleural Effusion, Malignant


This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


This is an open-label, non-randomized, multicenter, translational Phase 1/2 dose-escalation and expansion study designed to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of RSO-021 after intrapleural (IP) administration in patients with malignant pleural effusion (MPE) (non-mesothelioma) and MPE from mesothelioma.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Mar 2022 Apr 2025

Interventional

Intervention Type : Drug
Intervention Description : A naturally-occurring, sulfur-rich, cyclic oligopeptide antibiotic of the thiopeptide class.

Intervention Arm Group : P2 - Dose Expansion - mesothelioma -First line treatment prior to Ipi/Nivo;Ph2 - Dose Expansion - MPE from mesothelioma;Ph2 - Dose Expansion - MPE from non-mesothelioma solid tumors;Ph2 - Dose Expansion - MPE from non-mesothelioma solid tumors combination with Paclitaxel;Phase 1 - Dose Escalation



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • NHS Greater Glasgow & Clyde
    Glasgow
  • Facility: HOPE Clinical Trials Facility, Leicester Royal Infirmary
    Leicester
    LE1 5WW
  • Barts Health NHS Cancer Institute
    London
    EC1A7BE
  • Guys and St Thomas NHS Foundation Trust
    London
    SE19RT
  • The Royal Marsden
    London
    SW3 6JJ
  • The Christie NHS
    Manchester
    M204BX
  • Oxford University Hospitals NHS Foundation
    Oxford
    OX42PG
  • South Mead North Bristol Hopsital
    Bristol
    BS105NB
  • Leeds Teaching Hospital
    Leeds
    LS970F
  • Northumbria NorthTyne Side General Hospital
    North Shields
    NE29 8NH


The study is sponsored by RS Oncology LLC




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Read full details for Trial ID: NCT05278975
Last updated 25 January 2024

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