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Be Part of Research - Trial Details - Safety and Immunogenicity of a Candidate CHIKV Vaccine (CHIK001)

Safety and Immunogenicity of a Candidate CHIKV Vaccine (CHIK001)

Completed

Open to: ALL

Age: 18.0 - 50.0

Medical Conditions

Chikungunya Fever


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


A phase I dose escalation study to assess the safety and immunogenicity of the candidate vaccine ChAdOx1 Chik in healthy volunteers.

Volunteers will be recruited and vaccinated in Oxford, England.

All vaccinations will be administered intramuscularly. Three different doses will be tested (5x10\^9 vp, 2.5x10\^10 vp and 5x10\^10vp).

The total duration of the study will be 26 weeks from the day of enrolment for all volunteers.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jul 2018 Sep 2019

Publications

"Folegatti PM, Harrison K, Preciado-Llanes L, Lopez FR, Bittaye M, Kim YC, Flaxman A, Bellamy D, Makinson R, Sheridan J, Azar SR, Campos RK, Tilley M, Tran N, Jenkin D, Poulton I, Lawrie A, Roberts R, Berrie E, Rossi SL, Hill A, Ewer KJ, Reyes-Sandoval A. A single dose of ChAdOx1 Chik vaccine induces neutralizing antibodies against four chikungunya virus lineages in a phase 1 clinical trial. Nat Commun. 2021 Jul 30;12(1):4636. doi: 10.1038/s41467-021-24906-y."; "34330906"

INTERVENTIONAL

Intervention Type : BIOLOGICAL
Intervention Description : ChAdOx1 Chik, a replication-deficient simian adenoviral vector expressing CHIKV antigens.

Intervention Arm Group : Group 1;Group 2;Group 3;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital
    Oxford


The study is sponsored by University of Oxford




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Read full details for Trial ID: NCT03590392
Last updated 17 October 2019

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