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Be Part of Research - Trial Details - A Study of Bomedemstat (MK-3543) in Participants With Polycythemia Vera (MK-3543-004)

A Study of Bomedemstat (MK-3543) in Participants With Polycythemia Vera (MK-3543-004)

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Polycythemia Vera
Polycythemia


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study will evaluate the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics of the orally administered lysine-specific demethylase 1 (LSD1) inhibitor bomedemstat, in participants with polycythemia vera (PV). At Week 36 of dosing, participants will be assessed for eligibility to receive additional treatment through Week 52. Participants deriving clinical benefit and safely tolerating bomedemstat will qualify for continued treatment at the Investigator's discretion.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2023 Mar 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Oral tablet

Intervention Arm Group : Bomedemstat;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • United Lincolnshire Hospitals NHS Trust ( Site 0204)
    Lincoln
    Great Britain
    LN2 5QY
  • Imperial College London ( Site 0025)
    London
    Great Britain
    W12 0HS
  • Boston Pilgrim Hospital ( Site 0207)
    Boston
    Lincolnshire
    PE21 9QS
  • Royal Gwent Hospital ( Site 0201)
    Newport
    Wales
    NP9 2UB
  • Gloucestershire Royal Hospital ( Site 0205)
    Gloucester
    England
    GL1 3NN
  • Guys and St Thomas NHS Foundation Trust - Guys Hospital ( Site 0020)
    London
    London, City Of
    SE1 9RT


The study is sponsored by Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., (Rahway, New Jersey USA)




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Read full details for Trial ID: NCT05558696
Last updated 09 April 2025

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