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Be Part of Research - Trial Details - ABC-08: Phase Ib Trial of Acelarin in Combination With Cisplatin in Locally Advanced/ Metastatic Biliary Tract Cancers

ABC-08: Phase Ib Trial of Acelarin in Combination With Cisplatin in Locally Advanced/ Metastatic Biliary Tract Cancers

Completed

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Cholangiocarcinoma
Biliary Tract Neoplasms
Gallbladder Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to determine the recommended phase II dose, and to assess the safety of acelarin in combination with cisplatin in patients with locally advanced/ metastatic biliary tract cancers.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jan 2016 Mar 2019

Publications

"McNamara MG, Bridgewater J, Palmer DH, Faluyi O, Wasan H, Patel A, Ryder WD, Barber S, Gnanaranjan C, Ghazaly E, Evans TRJ, Valle JW. A Phase Ib Study of NUC-1031 in Combination with Cisplatin for the First-Line Treatment of Patients with Advanced Biliary Tract Cancer (ABC-08). Oncologist. 2021 Apr;26(4):e669-e678. doi: 10.1002/onco.13598. Epub 2020 Dec 3."; "33210382"

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : First-in-class nucleotide analogue

Intervention Arm Group : Acelarin & Cisplatin;

Intervention Type : DRUG
Intervention Description : Platinum-compound chemotherapy drug

Intervention Arm Group : Acelarin & Cisplatin;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Christie NHS Foundation Trust
    Manchester
  • University College London
    London
  • Clatterbridge Cancer Centre
    Liverpool
  • Imperial College London
    London
  • Beatson Oncology Centre
    Glasgow


The study is sponsored by The Christie NHS Foundation Trust




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Read full details for Trial ID: NCT02351765
Last updated 16 May 2023

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