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Be Part of Research - Trial Details - Sub-chronic Effects of 5-hydroxytryptophan on Mood and Emotional Processing in Healthy Volunteers

Sub-chronic Effects of 5-hydroxytryptophan on Mood and Emotional Processing in Healthy Volunteers

Completed

Open to: ALL

Age: 18.0 - 65.0

Medical Conditions


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


5-hydroxytryptophan (5-HTP) is a nutritional supplement sold in many health food stores, and is taken in order to raise levels of serotonin in the brain. Serotonin is a neurotransmitter that is involved in the regulation of mood.

Previous research has assessed the effects of raising serotonin levels using tryptophan (the precursor of 5-HTP) and serotonergic antidepressants on emotional processing in healthy volunteers. However, to date there has been no human trial investigating the effects of 5-HTP on emotional processing in healthy volunteers.

Thus, the current study aims to assess the effects of 5-HTP, on emotional processing and mood in healthy volunteers.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

May 2011 Aug 2011

INTERVENTIONAL

Intervention Type : DIETARY_SUPPLEMENT
Intervention Description : Thirty-three participants were randomly allocated in a double-blind manner to receive either 3x50mg capsules of 5-HTP or placebo (silica) for 14 days.

5-HTP is produced commercially by extraction from the seeds of the African plant griffonia simplicifolia.

Intervention Arm Group : 5-Hydroxytryptophan;

Intervention Type : DIETARY_SUPPLEMENT
Intervention Description : Pharmaceutical grade silica was utilized as placebo

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Northumbria University
    Newcastle Upon Tyne


The study is sponsored by Northumbria University





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Read full details for Trial ID: NCT01514409
Last updated 20 January 2012

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