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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Riti Desai, M.Sc.,M.Phil.
0044 2032991297
ritidesai@nhs.net
Lisa Ramazzotto, M.Pharm
0044 2032991297
kch-tr.tigerstudy@nhs.net
Eye Diseases Macular Degeneration, Wet Sub-Macular Hemorrhage
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
The centre of the retina (macula) at the back of the eye contains cells that give us our central vision that we use for reading and recognising faces. These cells can be damaged by a disease called wet age-related macular degeneration (AMD), where new abnormal blood vessels grow through the macula and leak fluid. This can affect vision. In some cases, wet AMD can also cause a bleed under the macula, known as a submacular haemorrhage (SMH), which can lead to marked and persistent loss of vision in the eye.
The current standard treatment for wet AMD is to give injections containing 'anti-VEGF' drugs into the eye. Anti-VEGF drugs reduce the leakage of fluid so that the macula can become dry again and sight can improve.
Anti-VEGFs are also the current standard of care for SMH, mainly because there is no licensed treatment for the SMH itself (patients with SMH were excluded from most wet AMD studies).
The purpose of this study therefore is to compare two treatments:
1. Standard treatment for wet AMD (anti-VEGF injections).
2. Standard treatment above plus surgery. This study will find out if having surgery alongside anti-VEGF injections can improve vision further over the current standard treatment of anti-VEGF injections alone.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
"Lee CN, Desai R, Ramazzotto L, Wafa H, Wang Y, Bunce C, Doungsong K, Ezeofor V, Edwards RT, Lois N, Steel DH, Peto T, Hillenkamp J, van Meurs JC, Reeves BC, Jackson TL. Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): update to study protocol and addition of a statistical analysis plan and health economic analysis plan for a randomised controlled surgical trial. Trials. 2025 Apr 14;26(1):131. doi: 10.1186/s13063-025-08727-8."; "40229856"; "Jackson TL, Bunce C, Desai R, Hillenkamp J, Lee CN, Lois N, Peto T, Reeves BC, Steel DH, Edwards RT, van Meurs JC, Wafa H, Wang Y. Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): study protocol for a phase 3, pan-European, two-group, non-commercial, active-control, observer-masked, superiority, randomised controlled surgical trial. Trials. 2022 Jan 31;23(1):99. doi: 10.1186/s13063-021-05966-3."; "35101110"
You can take part if:
You may not be able to take part if:
This is in the inclusion criteria above
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Lisa Ramazzotto, M.Pharm
0044 2032991297
kch-tr.tigerstudy@nhs.net
Riti Desai, M.Sc.,M.Phil.
0044 2032991297
ritidesai@nhs.net
The study is sponsored by King's College Hospital NHS Trust and is in collaboration with King's College London; Fight for Sight (Funder).
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
