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Be Part of Research - Trial Details - A Study to Evaluate the Efficacy and Safety of Eptinezumab for the Prevention of Migraine in Participants That Are Not Helped by Previous Preventive Treatments

A Study to Evaluate the Efficacy and Safety of Eptinezumab for the Prevention of Migraine in Participants That Are Not Helped by Previous Preventive Treatments

Completed

Open to: ALL

Age: 18.0 - 75.0

Medical Conditions

Migraine


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Evaluation of eptinezumab in the prevention of migraine in participants with unsuccessful prior preventive treatments.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jun 2020 Jul 2021

Publications

"Barbanti P, Awad SF, Rae-Espinoza H, Regnier SA, Lee XY, Goadsby PJ. Impact of eptinezumab on work productivity beyond reductions in monthly migraine days: post hoc analysis of the DELIVER trial. J Patient Rep Outcomes. 2024 Dec 18;8(1):146. doi: 10.1186/s41687-024-00813-w."; "39692817"; "Jonsson L, Awad SF, Regnier SA, Talon B, Kymes S, Lee XY, Goadsby PJ. Structural equation modeling for identifying the drivers of health-related quality of life improvement experienced by patients with migraine receiving eptinezumab. J Headache Pain. 2024 Mar 28;25(1):45. doi: 10.1186/s10194-024-01752-z."; "38549121"; "Pozo-Rosich P, Ashina M, Tepper SJ, Jensen S, Boserup LP, Josiassen MK, Sperling B. Eptinezumab Demonstrated Efficacy Regardless of Prior Preventive Migraine Treatment Failure Type: Post Hoc Analyses of the DELIVER Study. Neurol Ther. 2024 Apr;13(2):339-353. doi: 10.1007/s40120-023-00575-5. Epub 2024 Jan 18."; "38236314"; "Ashina M, Tepper SJ, Gendolla A, Sperling B, Ettrup A, Josiassen MK, Starling AJ. Long-term effectiveness of eptinezumab in patients with migraine and prior preventive treatment failures: extension of a randomized controlled trial. J Headache Pain. 2023 Nov 20;24(1):155. doi: 10.1186/s10194-023-01688-w."; "37985968"; "Jonsson L, Regnier SA, Kymes S, Awad SF, Talon B, Lee XY, Goadsby PJ. Estimating treatment effects on health utility scores for patients living with migraine: a post hoc analysis of the DELIVER trial. Expert Rev Pharmacoecon Outcomes Res. 2023 Jul-Dec;23(7):797-803. doi: 10.1080/14737167.2023.2219898. Epub 2023 Jun 2."; "37256558"; "Ashina M, Lanteri-Minet M, Ettrup A, Christoffersen CL, Josiassen MK, Phul R, Sperling B, Pozo-Rosich P. Efficacy and safety of eptinezumab for migraine prevention in patients with prior preventive treatment failures: subgroup analysis of the randomized, placebo-controlled DELIVER study. Cephalalgia. 2023 May;43(5):3331024231170807. doi: 10.1177/03331024231170807."; "37125484"; "Goadsby PJ, Barbanti P, Lambru G, Ettrup A, Christoffersen CL, Josiassen MK, Phul R, Sperling B. Eptinezumab improved patient-reported outcomes and quality of life in patients with migraine and prior preventive treatment failures. Eur J Neurol. 2023 Apr;30(4):1089-1098. doi: 10.1111/ene.15670. Epub 2023 Jan 21."; "36583633"; "Barbanti P, Goadsby PJ, Lambru G, Ettrup A, Christoffersen CL, Josiassen MK, Phul R, Sperling B. Effects of eptinezumab on self-reported work productivity in adults with migraine and prior preventive treatment failure in the randomized, double-blind, placebo-controlled DELIVER study. J Headache Pain. 2022 Dec 2;23(1):153. doi: 10.1186/s10194-022-01521-w."; "36460983"; "Ashina M, Lanteri-Minet M, Pozo-Rosich P, Ettrup A, Christoffersen CL, Josiassen MK, Phul R, Sperling B. Safety and efficacy of eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures (DELIVER): a multi-arm, randomised, double-blind, placebo-controlled, phase 3b trial. Lancet Neurol. 2022 Jul;21(7):597-607. doi: 10.1016/S1474-4422(22)00185-5."; "35716692"

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Eptinezumab, concentrate for solution for infusion 100 mg/milliliter (mL)

Intervention Arm Group : Eptinezumab 100 mg;Eptinezumab 300 mg;

Intervention Type : DRUG
Intervention Description : concentrate for solution for infusion, intravenously

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Synexus - Scotland Clinical Research Centre
    Bellshill
    England
    ML4 3NJ
  • Synexus - The Lancashire Clinic
    Chorley
    England
    PR7 7NA
  • Synexus Midlands Clinical Research Centre
    Edgbaston
    England
    B15 2SQ
  • Synexus - The Hexham Clinic
    Hexham
    England
    NE46 1QJ
  • Synexus - Merseyside Clinical Research Centre
    Liverpool
    England
    L22 0LG
  • Panthera Biopartners - North London
    London
    England
    EN3 4GS
  • Synexus - Manchester Clinical Research Centre
    Manchester
    England
    M15 6SE
  • Panthera Biopartners - Manchester
    Manchester
    England
    OL11 4AU
  • Panthera Biopartners - Preston
    Preston
    England
    PR2 9QB
  • Synexus - Thames Valley Clinical Research Centre
    Reading
    England
    RG2 0TG
  • Northern Care Alliance NHS Foundation Trust
    Salford
    England
    M6 8HD
  • Synexus - Wales
    Cardiff
    Wales
    CF15 9SS


The study is sponsored by H. Lundbeck A/S




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Read full details for Trial ID: NCT04418765
Last updated 08 September 2023

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