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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

AstraZeneca Clinical Study Information Center 1-877-240-9479
information.center@astrazeneca.com


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Be Part of Research - Trial Details - A Study to Investigate the Biological Effects of Saruparib (AZD5305), Darolutamide, and in Combination in Men With Newly Diagnosed Prostate Cancer.
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A Study to Investigate the Biological Effects of Saruparib (AZD5305), Darolutamide, and in Combination in Men With Newly Diagnosed Prostate Cancer.

Recruiting

Open to: MALE

Age: 18.0 - N/A

Cambridge Manchester Newcastle upon Tyne

Medical Conditions

Prostatic Neoplasms

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


A Study to Investigate the Biological Effects of Saruparib (AZD5305) Alone, Darolutamide Alone, and in Combination Given Prior to Radical Prostatectomy in Men with Newly Diagnosed Prostate Cancer (ASCERTAIN).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2023 Nov 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Saruparib (AZD5305) given orally once daily

Intervention Arm Group : Saruparib (AZD5305) + Darolutamide;Saruparib (AZD5305) only;

Intervention Type : DRUG
Intervention Description : Darolutamide tablet is 300mg, given BD orally, twice daily- total dose 1200mg

Intervention Arm Group : Darolutamide Only;Saruparib (AZD5305) + Darolutamide;

Intervention Type : OTHER
Intervention Description : No study treatment is to be taken by the participants in this arm. Radical prostatectomy should be performed as per local practice

Intervention Arm Group : No Treatment;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    Cambridge
    CB2 0QQ
  • Research Site
    Manchester
    M20 4BX
  • Research Site
    Newcastle upon Tyne
    NE7 7AF

AstraZeneca Clinical Study Information Center 1-877-240-9479
information.center@astrazeneca.com



The study is sponsored by AstraZeneca




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Read full details for Trial ID: NCT05938270
Last updated 25 April 2025

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