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Be Part of Research - Trial Details - Nitric Oxide (NO) Donors and Inhibitors Study: Study to Evaluate L-Arginine and Aminoguanidine in Asthmatic Subjects

Nitric Oxide (NO) Donors and Inhibitors Study: Study to Evaluate L-Arginine and Aminoguanidine in Asthmatic Subjects

Completed

Open to: ALL

Age: 21.0 - 60.0

Medical Conditions

Asthma


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The primary aim of this study is to investigate the effects of oral and inhaled administration of L-arginine and of inhaled aminoguanidine on bronchial and alveolar exhaled NO and NO metabolites in exhaled breath condensate, saliva and nasal lavage fluid in normal and asthmatic subjects.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2003 Mar 2005

Publications

"Brindicci C, Ito K, Barnes PJ, Kharitonov SA. Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers. Chest. 2007 Aug;132(2):581-8. doi: 10.1378/chest.06-3046. Epub 2007 Jun 5."; "17550932"

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : 500mg

Intervention Arm Group : Asthma volunteers;

Intervention Type : DRUG
Intervention Description : 2ml

Intervention Arm Group : Healthy volunteers;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Section of Airway Disease, Asthma Lab, Imperial College London, Royal Brompton Hospital
    London
    SW3 6LY


The study is sponsored by Imperial College London




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Read full details for Trial ID: NCT00159380
Last updated 09 July 2019

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