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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Abigail Miss Temple 0208 642 6011
Abigail.Temple@rmh.nhs.uk


Lucinda Dr Gunn, Dr 0207 352 8171
Lucinda.Gunn@rmh.nhs.uk


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Be Part of Research - Trial Details - Gustatory Function Following Radiotherapy to the Head and Neck
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Gustatory Function Following Radiotherapy to the Head and Neck

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

London

Medical Conditions

Head and Neck Neoplasms

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The aim of this study is to assess the effect of RT or chemo-RT on chemosensory gustatory function in patients with HNC. By using detailed dosimetric data derived from the RT planning system, we will be able to calculate mean radiation doses to important structures including the anterior and posterior tongue, oral cavity, parotid and submandibular salivary glands, and correlate them with both qualitative and quantitative data for dysgeusia.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Aug 2018 Mar 2020

OBSERVATIONAL

Intervention Type : OTHER
Intervention Description : Therefore prior to gustatory testing, patients will be screened and assessed as having either normal or abnormal olfactory function using the Sniffin' Sticks (Burghart; Wedel, Germany). The test consists of 12 odour pens which represent every-day odours (peppermint, fish, coffee, banana, orange, rose, lemon, pineapple, cinnamon, cloves, leather and liquorice). Patients are presented with an odour and select the perceived smell using a multiple-forced-choice method.

Intervention Arm Group : On Study;

Intervention Type : OTHER
Intervention Description : Following screening for olfactory function, whole mouth gustatory function will be assessed using validated taste strips (Burghart; Wedel, Germany). Filter paper test strips are impregnated at one end with 2cm2 of either sweet, sour, salty or bitter taste solutions in four concentrations. In a pseudo-randomised sequence, individual strips will be placed on the tongue and patients will be asked to close their mouth in order to assess whole mouth function. Through a forced-choice procedure patients will be asked to identify the taste stimuli. Scores for individual taste qualities will range from 0-4 and an overall taste score will range from 0-16.

Patients will rinse their mouth with tap water prior the application of each taste strip.

Intervention Arm Group : On Study;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Head and Neck Unit, Royal Marsden Hospital
    London
    SW3 6JJ

Lucinda Dr Gunn, Dr 0207 352 8171
Lucinda.Gunn@rmh.nhs.uk


Abigail Miss Temple 0208 642 6011
Abigail.Temple@rmh.nhs.uk



The study is sponsored by Royal Marsden NHS Foundation Trust



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Read full details for Trial ID: NCT03738657
Last updated 08 November 2018

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