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Be Part of Research - Trial Details - A Phase 1 Study of MEDI4736 in Combination With Tremelimumab in Subjects With Advanced Solid Tumors

A Phase 1 Study of MEDI4736 in Combination With Tremelimumab in Subjects With Advanced Solid Tumors

Completed

Open to: ALL

Age: 18.0 - 99.0

Medical Conditions

Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a multicenter, open-label, dose-exploration and dose-expansion study to evaluate the safety, tolerability, antitumor activity, PK and immunogenicity of MEDI4736 in combination with tremelimumab in subjects with select advanced solid tumors.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Oct 2014 Jan 2020

Publications

"Zhang Q, Luo J, Wu S, Si H, Gao C, Xu W, Abdullah SE, Higgs BW, Dennis PA, van der Heijden MS, Segal NH, Chaft JE, Hembrough T, Barrett JC, Hellmann MD. Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade. Cancer Discov. 2020 Dec;10(12):1842-1853. doi: 10.1158/2159-8290.CD-20-0047. Epub 2020 Aug 14."; "32816849"

INTERVENTIONAL

Intervention Type : BIOLOGICAL
Intervention Description : MEDI4736 is administered by IV infusion in combination with tremelimumab

Intervention Arm Group : MEDI4736 + Tremelimumab;

Intervention Type : BIOLOGICAL
Intervention Description : Tremelimumab is administered by IV infusion in combination with MEDI4736

Intervention Arm Group : MEDI4736 + Tremelimumab;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    London
    EC1M 6BQ
  • Research Site
    Oxford
    OX3 7LE
  • Research Site
    Wirral
    CH63 4JY
  • Research Site
    Glasgow
    G12 0YN
  • Research Site
    Middlesborough
    TS4 3BW
  • Research Site
    London
    NW1 2BU


The study is sponsored by MedImmune LLC




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Read full details for Trial ID: NCT02261220
Last updated 05 March 2020

This page is to help you find out about a research study and if you may be able to take part

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