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Be Part of Research - Trial Details - A Study for Older Adults With Acute Lymphoblastic Leukaemia

A Study for Older Adults With Acute Lymphoblastic Leukaemia

Medical Conditions

Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Lymphoid


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The NCRI Adult ALL sub-group propose to collaborate with the Dutch/Belgian group HOVON to carry out a prospective, non randomised multi-arm study (including a choice of regimen intensity) to investigate the safety, tolerability and feasibility of a standardised therapy protocol for patients ≥ 60 years old with de novo ALL. The overall aim is define a basic standard of care upon which trials of novel therapies will be based in future. The design of the study will enable collection of a comprehensive dataset regarding the clinical outcome, Complete Response Rate (CR) and Minimal Residual Disease (MRD) response rates in a previously completely uncharacterised population, thus providing the essential platform for designing future randomised advanced phase studies in which new therapeutic approaches and novel therapies can be prospectively investigated.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2012 Dec 2018

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Treatment for all pathways consists of Induction, Intensification (where applicable), Consolidation and Maintenance therapy during which combination chemotherapy is given for up to 2.5 years.

Intervention Arm Group : Philadelphia -ve Patients- Intensive;Philadelphia -ve Patients- Intensive +;Philadelphia -ve Patients- Non Intensive;Philadelphia Positive Patients;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • St George's Hospital
    London
  • Royal Hallamshire Hospital
    Sheffield
  • Royal Bournemouth Hospital
    Bournemouth
  • Royal Liverpool University Hospital
    Liverpool
  • Ninewells Hospital
    Dundee
  • Russells Hall Hospital
    Dudley
  • Poole General Hospital
    Poole
  • Bradford Royal Infirmary
    Bradford
  • Northwick Park Hospital
    Harrow
  • Derriford Hospital
    Plymouth
  • Leicester Royal Infirmary
    Leicester
  • Beatson West of Scotland Cancer Centre
    Glasgow
  • St Bartholomew's Hospital
    London
  • The Christie Hospital
    Manchester
  • James Cook University Hospital
    Middlesbrough
  • Great Western Hospital
    Swindon
  • Bristol Haematology and Oncology Centre
    Bristol
  • Torbay Hospital
    Torquay
  • Castle Hill Hospital
    Cottingham
  • Salisbury District Hospital
    Salisbury
  • NHS Lothian - Western General Hospital
    Edinburgh
  • Arrowe Park Hospital
    Wirral
  • NHS Lanarkshire - Monklands
    Airdrie
  • Blackpool Victoria Hopsital
    Blackpool
  • New Victoria Hospital and Southern General Hospital
    Glasgow
  • St James' Hospital, Leeds
    Leeds
  • Churchill Hospital, Oxford
    Oxford
  • St Helen's & Knowlsey Teaching Hospitals
    Prescot
  • Royal MarsdenHospital
    Sutton
  • Musgrove Park
    Taunton
  • Sandwell General Hospital
    West Bromwich
  • University Hospital of Wales
    Cardiff
  • King's College Hospital NHS Foundation Trust
    London


The study is sponsored by University College, London and is in collaboration with Cancer Research UK; Stichting Hemato-Oncologie voor Volwassenen Nederland.




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Read full details for Trial ID: NCT01616238
Last updated 15 August 2023

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