Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Michael Yee 650-839-7361
myee@kartosthera.com


John Mei 650-542-0136
jmei@kartosthera.com


Study Location:

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Be Part of Research - Trial Details - Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL

Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Lymphoma
Leukemia
Lymphoma, B-Cell
Leukemia, Lymphoid
Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma, Large B-Cell, Diffuse


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, combined with acalabrutinib for the treatment of adults with Diffuse Large B-Cell Lymphoma and Chronic Lymphocytic Leukemia. Participants must be relapsed/refractory (having failed prior therapy)

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2021 Oct 2022

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : KRT-232 is an experimental MDM2 inhibitor anticancer drug taken by mouth

Intervention Arm Group : Cohort 1 (R/R DLBCL);Cohort 2 (R/R CLL);

Intervention Type : DRUG
Intervention Description : acalabrutinib is a BTK inhibitor anticancer drug taken by mouth

Intervention Arm Group : Cohort 1 (R/R DLBCL);Cohort 2 (R/R CLL);



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • King's College Hospital
    London
  • University Hospital Southampton NHS Foundation Trust
    Southampton
  • St James's University Hospital
    Leeds
  • Royal Marsden Foundation Trust
    London


The study is sponsored by Kartos Therapeutics, Inc.




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Read full details for Trial ID: NCT04502394
Last updated 03 August 2022

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