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Be Part of Research - Trial Details - To Assess the Safety of Continuous IV Administration of Plerixafor and Assess Impact on the Immune Microenvironment in Patients With Pancreatic, Ovarian and Colorectal Adenocarcinomas

To Assess the Safety of Continuous IV Administration of Plerixafor and Assess Impact on the Immune Microenvironment in Patients With Pancreatic, Ovarian and Colorectal Adenocarcinomas

Stopped

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Adenocarcinoma
Pancreatic Neoplasms


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A dose escalation trial to assess the safety of plerixafor in patients with advanced pancreatic, high grade serous ovarian and colorectal cancer. To identify the proof of mechanism, by demonstrating alterations in T-cell tumour distribution, ideally associated with loss of tumour cells, measured by immunostaining, and changes in FDG uptake.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jul 2017 Dec 2019

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Plerixafor will be administered via IV as a continuous 7 day intravenous infusion starting at a dose of 20 ug/kg/hr and subsequent dose levels of 40, 80 and 120 ug/kg/hr

Intervention Arm Group : All Subjects;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Cambridge University Hospitals NHS Foundation Trust
    Cambridge
    CB2 0QQ


The study is sponsored by Weill Medical College of Cornell University and is in collaboration with Cambridge University Hospitals NHS Foundation Trust.




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Read full details for Trial ID: NCT03277209
Last updated 27 February 2020

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