Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

AstraZeneca Breast Cancer Study Locator Service +1-877-400-4656
az-bcsl@careboxhealth.com


AstraZeneca Clinical Study Information Center 1-877-240-9479
information.center@astrazeneca.com


Study Location:

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English | Cymraeg
Be Part of Research - Trial Details - A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Breast Neoplasms
Triple Negative Breast Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a Phase III, randomised, open-label, 3-arm, multicentre, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with investigator's choice chemotherapy in combination with pembrolizumab in participants with PD-L1 positive locally recurrent inoperable or metastatic TNBC.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2023 Dec 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Provided in 100mg vials. IV infusion. Experimental drug.

Intervention Arm Group : Dato-DXd;Dato-DXd + durvalumab;

Intervention Type : DRUG
Intervention Description : Provided in 500mg vials. IV infusion. Experimental drug.

Intervention Arm Group : Dato-DXd + durvalumab;

Intervention Type : DRUG
Intervention Description : IV infusion. Active comparator.

Intervention Arm Group : Investigator's Choice of Chemotherapy (ICC) in combination with pembrolizumab;

Intervention Type : DRUG
Intervention Description : IV infusion. Active comparator.

Intervention Arm Group : Investigator's Choice of Chemotherapy (ICC) in combination with pembrolizumab;

Intervention Type : DRUG
Intervention Description : IV infusion. Active comparator.

Intervention Arm Group : Investigator's Choice of Chemotherapy (ICC) in combination with pembrolizumab;

Intervention Type : DRUG
Intervention Description : IV infusion. Active comparator.

Intervention Arm Group : Investigator's Choice of Chemotherapy (ICC) in combination with pembrolizumab;

Intervention Type : DRUG
Intervention Description : IV infusion. Active comparator.

Intervention Arm Group : Investigator's Choice of Chemotherapy (ICC) in combination with pembrolizumab;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    Sutton
    SM2 5PT
  • Research Site
    Oxford
    OX3 7LE
  • Research Site
    London
    SW17 0QT
  • Research Site
    London
    EC1A 7BE
  • Research Site
    Chelsea
    SW3 6JJ
  • Research Site
    Taunton
    TA1 5DA
  • Research Site
    Cardiff
    CF14 2TL
  • Research Site
    Liverpool
    L7 8YA
  • Research Site
    Surrey
    GU2 7XX
  • Research Site
    Leicester
    Le5 4PW

AstraZeneca Clinical Study Information Center 1-877-240-9479
information.center@astrazeneca.com


AstraZeneca Breast Cancer Study Locator Service +1-877-400-4656
az-bcsl@careboxhealth.com



The study is sponsored by AstraZeneca and is in collaboration with Daiichi Sankyo.





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Read full details for Trial ID: NCT06103864
Last updated 28 April 2025

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