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Be Part of Research - Trial Details - A Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease.

A Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease.

Completed

Open to: ALL

Age: 40.0 - 85.0

Medical Conditions

Parkinson Disease


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a multi-center, randomized, double blind, adaptive, parallel-group, placebo controlled Phase 1b study to evaluate the safety, tolerability, pharmacokinetic (PK) and pharmacodynamics of RO7486967 in participants with idiopathic PD at the early stage of the disease (modified H\&Y stage ≤2.5) who are either treatment-naïve or on stable treatment with symptomatic therapy (levodopa and/or pramipexole, ropinirole, rotigotine).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2022 Jul 2024

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : For up to approximately 28 days

Intervention Arm Group : RO7486967 Arm;

Intervention Type : DRUG
Intervention Description : For up to approximately 28 days

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Barts Health NHS Trust
    London
    E1 2ES
  • University of Exeter
    Exeter
    EX4 4RN
  • Imperial College Healthcare NHS Trust; Charing Cross Hospital
    London
    W6 8RF
  • National Hospital for Neurology and Neurosurgery; Leonard Wolfson Experimental Neurology Centre CRF
    London
    WC1N 3BG
  • Campus for Ageing & Vitality; Clincal Ageing Research Unit
    Newcastle
    NE4 5PL


The study is sponsored by Hoffmann-La Roche





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Read full details for Trial ID: NCT05924243
Last updated 16 September 2024

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