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Be Part of Research - Trial Details - Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study will evaluate the efficacy and safety of olaparib (MK-7339) monotherapy in participants with multiple types of advanced cancer (unresectable and/or metastatic) that: 1) have progressed or been intolerant to standard of care therapy; and 2) are positive for homologous recombination repair mutation (HRRm) or homologous recombination deficiency (HRD).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2018 Jun 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Olaparib 300 mg administered BID as two, 150 mg oral tablets.

Intervention Arm Group : Olaparib;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Churchill Hospital ( Site 1606)
    Oxford
    Worcestershire
    OX3 7LE
  • Christie NHS Foundation Trust ( Site 1601)
    Manchester
    M20 4BX
  • Northern Centre for Cancer Care ( Site 1602)
    Newcastle Upon Tyne
    NE7 7DN
  • Weston Park Hospital ( Site 1607)
    Sheffield
    S10 2SJ


The study is sponsored by Merck Sharp & Dohme LLC and is in collaboration with AstraZeneca.




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Read full details for Trial ID: NCT03742895
Last updated 06 December 2024

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