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Be Part of Research - Trial Details - Melatonin in Pregnancy
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Melatonin in Pregnancy

Completed

Open to: Female

Age: 16 Years - 45 Years

Aberdeen Ellon

Medical Conditions

Pregnancy

This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


Melatonin is well known for its role in the sleep-wake cycle and is synthesised in response to low light levels from the pineal gland. In our previous study it was found that serum melatonin levels increased dramatically during pregnancy, such that levels were up to 100 fold higher in the third trimester compared to healthy non-pregnant women. The placenta contains the enzymes which are involved in synthesising melatonin but it is unclear if this is the source of the high levels in pregnancy. Severe pre-eclampsia has been reported to be associated with low levels of melatonin. In this study its is proposed to measure serum melatonin immediately before and after delivery and in cord blood and relate the levels to those in the placenta itself. This will contribute to the potential role for melatonin as a biomarker for obstetric disease and potentially as a therapeutic agent in future. This observational pilot study aims to measure serum and placental melatonin levels (as the major metabolite 6-hydroxymelatonin sulphate) in pregnant women undergoing elective Caesarean section.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jun 2018 Aug 2018

Observational

Intervention Type : Other
Intervention Description : Measurement of 6-hydroxymelatonin




You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University of Aberdeen/NHS Grampian
    Aberdeen
    If Already Stated Select NOT Listed
    AB25 2ZD
  • Aberdeen Maternity Hospital
    Ellon
    Lowland Scotland
    AB25 2ZB


The study is sponsored by University of Aberdeen and funded by NHS Grampian.



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Read full details for Trial ID: NCT03609086
Last updated 17 February 2021

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