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Contact Information:

Susan O'Connor 07513017280
susan.oconnor@blctrials.onmicrosoft.com


Jake Taylor-King, DPhil 447387227904
jake@relationrx.com


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Be Part of Research - Trial Details - OSTEOMICS: Identifying Regulators of Bone Homeostasis

OSTEOMICS: Identifying Regulators of Bone Homeostasis

Recruiting

Open to: ALL

Age: 18.0 - 110.0

Medical Conditions

Osteoporosis
Bone Diseases
Bone Marrow Diseases
Fractures, Bone


This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


Diseases of bone associated with ageing, including osteoporosis (OP) and osteoarthritis (OA), reduce bone mass, bone strength and joint integrity. Current non-surgical approaches are limited to pharmaceutical agents that are not disease modifying and have poor patient tolerability due to side effect profiles. Developing a fundamental understanding of cellular bone homeostasis, including how key cell types affect tissue health, and offering novel therapeutic targets for prevention of bone disease is therefore essential. This is the focus of OSTEOMICS.

A number of factors have been linked to increased risk of bone disease, including genetic predisposition, diet, smoking, ageing, autoimmune disorders and endocrine disorders. In our study, we will recruit patients undergoing elective and non-elective orthopaedic surgery and obtain surgical bone waste for analysis. This will capture a cohort of patients with bone disorders like OP and OA, in addition to patients without overt clinical bone disease. We will study the relationship between the molecular biology of bone cells, bone structure, genetics (DNA) and environmental factors with the aim of identifying and validating novel therapeutic targets.

We will leverage modern single cell technologies to understand the diversity of cell types found in bone. These technologies have now led to the characterisation of virtually every tissue in the body, however bone and bone-adjacent tissues are massively underrepresented due to the anatomical location and underlying technical challenges. Early protocols to demineralise bone and perform single cell profiling have now been developed. We will systematically scale up these efforts to observe how genetic variation at the population level leads to alterations in bone structure and quality.

Over the next 10 years, we will generate data to comprehensively characterise bone across health and disease, use machine learning to drive analysis, and experimentally validate hypotheses - which will ultimately contribute to developing the next generation of therapeutic agents.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jan 2023 Dec 2027

OBSERVATIONAL

Intervention Type : PROCEDURE
Intervention Description : Inclusion criteria is purposefully broad to examine a range of discarded bone waste. Therefore, a large number of surgical interventions are relevant.

Intervention Arm Group : Participant undergoing orthopaedic surgery;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • King's College Hospital
    London
  • Barts Health NHS Trust
    London
  • West Middlesex University Hospital
    London
  • Harley Street Specialist Hospital
    London
    Greater London
    W1G 8HU
  • Chase Farm Hospital
    London
  • Fitzrovia Hospital/QASMC
    London
  • Luton & Dunstable University Hospital
    London
  • Royal National Orthopaedic Hospital NHS Trust
    London


The study is sponsored by Relation Therapeutics and is in collaboration with Harley Street Specialist Hospital; Fitzrovia Hospital; Royal Free Hospital NHS Foundation Trust; Bedfordshire Hospitals NHS Foundation Trust; Chelsea and Westminster NHS Foundation Trust; Barts & The London NHS Trust; Royal National Orthopaedic Hospital NHS Trust.




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Read full details for Trial ID: NCT05732870
Last updated 20 February 2024

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