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Be Part of Research - Trial Details - A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor

A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Diabetes Mellitus
Diabetes Mellitus, Type 2


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The study will look at how well CagriSema helps people lower their blood sugar and body weight. CagriSema is a new weekly medicine that combines two medicines called semaglutide and cagrilintide. CagriSema will be compared to the two medicines semaglutide and cagrilintide, when they are taken alone. CagriSema will also be compared to a "dummy" medicine without any active ingredient. The study will be done in participants who have type 2 diabetes. Participants will take the study medicine together with the current diabetes medicine (metformin with or without an SGLT2 inhibitor).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2023 Nov 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Participants will receive once-weekly s.c injection of cagrilintide at escalating doses every week until maintenance dose 1 and dose 2 of cagrilintide is reached.

Intervention Arm Group : CagriSema Dose 1;CagriSema Dose 2;Cagrilintide Dose 1;

Intervention Type : DRUG
Intervention Description : Participants will receive once-weekly s.c injection of semaglutide at escalating doses every week until maintenance dose 1 and dose 2 of semaglutide is reached.

Intervention Arm Group : CagriSema Dose 1;CagriSema Dose 2;Semaglutide Dose 1;Semaglutide Dose 2;

Intervention Type : DRUG
Intervention Description : Participants will receive placebo matched to cagrilintide subcutaneously.

Intervention Arm Group : Placebo Dose 1;Placebo Dose 2;

Intervention Type : DRUG
Intervention Description : Participants will receive placebo matched to semaglutide subcutaneously.

Intervention Arm Group : Placebo Dose 1;Placebo Dose 2;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Ninewells Hospital
    Dundee
    DD1 9SY
  • Pickering Medical Practice
    Pickering
    YO18 8BL
  • University Hospital Aintree
    Liverpool
    L9 7AL
  • Lister Hospital
    Stevenage
    Hertfordshire
    SG1 4AB
  • Oldfield Surgery
    Bath
    BA2 3HT
  • Aberdeen Royal Infirmary
    Aberdeen
    AB25 2ZP
  • Moorgreen Hospital
    Southampton
    SO30 3JB
  • Joint Clinical Research Facility - Swansea
    Swansea
    SA2 8PP
  • Royal Cornwall Hospital (Treliske)
    Truro
    TR1 3LJ
  • Oakenhurst Surgery
    Blackburn
    BB2 1AX
  • Norfolk and Norwich University Hospital Trust
    Norwich
    NR4 7UY


The study is sponsored by Novo Nordisk A/S





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Read full details for Trial ID: NCT06065540
Last updated 08 April 2025

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