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Be Part of Research - Trial Details - An Efficacy, Safety, Tolerability and Dose Finding Study of XXB750 in Resistant Hypertension Patients.

An Efficacy, Safety, Tolerability and Dose Finding Study of XXB750 in Resistant Hypertension Patients.

Completed

Open to: ALL

Age: 18.0 - 100.0

Medical Conditions

Hypertension


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this 20-week randomized double-blind study in patients with resistant hypertension (rHTN) is to evaluate the efficacy, safety, and tolerability, of different doses of XXB750 administered as subcutaneous (SC) injections, compared to placebo. Since all study participants will be patients with rHTN, all study treatments will be given on top of maximally tolerated background antihypertensive therapy recommended by international guidelines for treatment of HTN (i.e., a thiazide or a thiazide-like diuretic, an angiotensin converting enzyme inhibitor (ACEi) or an angiotensin receptor blocker (ARB), and a long-acting dihydropyridine calcium channel blocker (CCB).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2022 Jul 2024

INTERVENTIONAL

Intervention Type : BIOLOGICAL
Intervention Description : SC injection

Intervention Arm Group : Dose 1;Dose 2;Dose 3;Dose 4;

Intervention Type : OTHER
Intervention Description : SC injection

Intervention Arm Group : Dose 5;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Novartis Investigative Site
    London
    GBR
    EC1M 6BQ
  • Novartis Investigative Site
    London
    W1T 7HA
  • Novartis Investigative Site
    Salford
    M6 8HD


The study is sponsored by Novartis Pharmaceuticals




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Read full details for Trial ID: NCT05562934
Last updated 26 December 2024

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