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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Alexander Cowley, PhD
+44 (0) 20 3437 6927
alexander.cowley@icr.ac.uk
Anna Zachariou, PhD
anna.zachariou@icr.ac.uk
Carcinoma, Non-Small-Cell Lung
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
HyPeR is a multi-centre Phase 1 Dose Escalation Study of Guadecitabine (SGI-110)/ASTX727 a Second Generation Hypo-Methylating Agent in Combination with Pembrolizumab (MK3475) in Patients with Refractory Solid Tumours. The investigators will be investigating the safety and toxicity of the combination.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
"Papadatos-Pastos D, Yuan W, Pal A, Crespo M, Ferreira A, Gurel B, Prout T, Ameratunga M, Chenard-Poirier M, Curcean A, Bertan C, Baker C, Miranda S, Masrour N, Chen W, Pereira R, Figueiredo I, Morilla R, Jenkins B, Zachariou A, Riisnaes R, Parmar M, Turner A, Carreira S, Yap C, Brown R, Tunariu N, Banerji U, Lopez J, de Bono J, Minchom A. Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumors. J Immunother Cancer. 2022 Jun;10(6):e004495. doi: 10.1136/jitc-2022-004495."; "35717027"
You can take part if:
You may not be able to take part if:
This is in the inclusion criteria above
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Anna Zachariou, PhD
anna.zachariou@icr.ac.uk
Alexander Cowley, PhD
+44 (0) 20 3437 6927
alexander.cowley@icr.ac.uk
The study is sponsored by Royal Marsden NHS Foundation Trust and is in collaboration with Astex Pharmaceuticals, Inc.; Merck Sharp & Dohme LLC; Institute of Cancer Research, United Kingdom.
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
