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Be Part of Research - Trial Details - Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Neoplasms
Leukemia, Lymphocytic, Chronic, B-Cell
Hematologic Neoplasms
Waldenstrom Macroglobulinemia


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to evaluate the safety and efficacy of nemtabrutinib (formerly ARQ 531) in participants with hematologic malignancies of chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL), Richter's transformation, marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and Waldenström's macroglobulinemia (WM).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Apr 2021 Mar 2027

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Nemtabrutinib tablets administered PO QD.

Intervention Arm Group : Nemtabrutinib;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Bristol Haematology and Oncology Centre ( Site 2610)
    Bristol
    Bristol, City Of
    BS2 8ED
  • Nottingham University Hospitals NHS Trust. City Hospital Campus ( Site 2601)
    Nottingham
    England
    NG5 1PF
  • GenesisCare - Windsor ( Site 2608)
    Windsor
    England
    SL4 3HD
  • Sarah Cannon Research Institute UK ( Site 2612)
    London
    London, City Of
    W1G 6AD
  • GenesisCare - Oxford ( Site 2607)
    Oxford
    Oxfordshire
    OX4 6LB
  • GenesisCare - Cambridge ( Site 2611)
    Newmarket
    Suffolk
    CB8 7XN
  • The Christie NHS Foundation Trust ( Site 2602)
    Manchester
    M20 4BX
  • The Royal Marsden NHS Foundation Trust. ( Site 2606)
    Sutton
    Surrey
    SM2 5PT


The study is sponsored by Merck Sharp & Dohme LLC




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Read full details for Trial ID: NCT04728893
Last updated 17 April 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.