Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Sarah F Powell-Brett, MRCS 07887754856
sarah.powell-brett1@nhs.net


Nikolaos A Chatzizacharias, FRCS 07787731126
Nikolaos.Chatzizacharias@uhb.nhs.uk


Study Location:

Find another location


Questions to ask
Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - The DISSECT Study: Effect of Peri-aDventItial SMA diSsECtion on Margin sTatus During Pancreaticoduodenectomy for Resectable Pancreatic Cancer
Back

The DISSECT Study: Effect of Peri-aDventItial SMA diSsECtion on Margin sTatus During Pancreaticoduodenectomy for Resectable Pancreatic Cancer

Recruiting

Open to: ALL

Age: 18.0 - N/A

Birmingham

Medical Conditions

Pancreatic Neoplasms

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


There is a high rate of R1 resection following patients undergoing pancreaticoduodenectomy for pancreatic cancer. The most commonly positive margin is the SMA. Peri-adventitial dissection has been proposed as an effective method of achieving R0 margins. There is lack of standardisation of the proposed technique and no grade 1 evidence to support routine use of this technique.

The goal of this randomised controlled trial is to investigate the role of routine peri-adventitial dissection on the SMA margin status.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Apr 2021 Oct 2026

INTERVENTIONAL

Intervention Type : PROCEDURE
Intervention Description : lymphoneural tissue around SMA left intact

Intervention Arm Group : NO periadventitial dissection;

Intervention Type : PROCEDURE
Intervention Description : For the patients randomised for peri-adventitial dissection the right side of the SMA should be completely clear from lymphoneural tissue for at least 180 degrees on right side and from "angle" of the artery to the level of inferior border of the uncinate process. In the presence of an accessory or replaced right hepatic artery the peri-adventitial dissection should also be carried out around this vessel as well.

Intervention Arm Group : Periadventitial dissection;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University Hospitals Birmingham NHS Foundation Trust
    Birmingham
    County (Optional)
    B15 2GW

Nikolaos A Chatzizacharias, FRCS 07787731126
Nikolaos.Chatzizacharias@uhb.nhs.uk


Sarah F Powell-Brett, MRCS 07887754856
sarah.powell-brett1@nhs.net



The study is sponsored by University Hospital Birmingham NHS Foundation Trust



We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?
Read full details for Trial ID: NCT04902352
Last updated 16 December 2024

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

Back to the top