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Be Part of Research - Trial Details - A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment

A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Multiple Myeloma
Neoplasms, Plasma Cell


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of the study is to compare the efficacy of talquetamab subcutaneous(ly) (SC) in combination with daratumumab SC and pomalidomide (Tal-DP) and talquetamab SC in combination with daratumumab SC (Tal-D), respectively, with daratumumab SC in combination with pomalidomide and dexamethasone (DPd).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Oct 2022 Feb 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Talquetamab will be administered subcutaneously.

Intervention Arm Group : Arm A: Talquetamab Subcutaneous (SC) in Combination With Daratumumab SC and Pomalidomide (Tal-DP);Arm C: Talquetamab SC in Combination With Daratumumab SC (Tal-D);

Intervention Type : DRUG
Intervention Description : Daratumumab will be administered subcutaneously.

Intervention Arm Group : Arm A: Talquetamab Subcutaneous (SC) in Combination With Daratumumab SC and Pomalidomide (Tal-DP);Arm B: Daratumumab in Combination With Pomalidomide and Dexamethasone (DPd);Arm C: Talquetamab SC in Combination With Daratumumab SC (Tal-D);

Intervention Type : DRUG
Intervention Description : Pomalidomide will be administered orally.

Intervention Arm Group : Arm A: Talquetamab Subcutaneous (SC) in Combination With Daratumumab SC and Pomalidomide (Tal-DP);Arm B: Daratumumab in Combination With Pomalidomide and Dexamethasone (DPd);

Intervention Type : DRUG
Intervention Description : Dexamethasone will be administered orally or intravenously.

Intervention Arm Group : Arm A: Talquetamab Subcutaneous (SC) in Combination With Daratumumab SC and Pomalidomide (Tal-DP);Arm B: Daratumumab in Combination With Pomalidomide and Dexamethasone (DPd);Arm C: Talquetamab SC in Combination With Daratumumab SC (Tal-D);



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Hammersmith Hospital
    London
    W12 0HS
  • Blackpool Victoria Hospital
    Blackpool
    FY3 8NR
  • New Cross Hospital
    Wolverhampton
    WV10 0QP
  • Nottingham City Hospital
    Nottingham
    NG5 1PB
  • Ninewells Hospital & Medical School
    Dundee
    DD1 9SY
  • Royal Marsden Hospital
    Sutton
    SM2 5PT
  • University Hospitals Plymouth NHS Trust
    Plymouth
    PL6 8DH
  • Newcastle Freeman Hospital
    Newcastle Upon Tyne
    NE7 7DN


The study is sponsored by Janssen Research & Development, LLC




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Read full details for Trial ID: NCT05455320
Last updated 25 April 2025

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