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Contact Information:

Ms Alexis Perkins
None available
alexis.perkins20@imperial.ac.uk


Prof Nicholas Hopkinson
+44 (0)20 73497775
n.hopkinson@ic.ac.uk


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Be Part of Research - Trial Details - Improving the experience of physical activity in people with severe lung disease using dietary nitrate supplementation with beetroot juice
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Improving the experience of physical activity in people with severe lung disease using dietary nitrate supplementation with beetroot juice

Recruiting

Open to: All Genders

Age: Adult

Brighton Leicester London London London London

Medical Conditions

Chronic obstructive pulmonary disease

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


People with a lung disease called chronic obstructive pulmonary disease (COPD) who need to use oxygen at home are usually limited in what they can do on a day-to-day basis. In COPD, breathlessness and fatigue during daily activities are usually due to a combination of lung problems, the heart having to work harder and the muscles not being very good at using oxygen. Nitrate is a natural product found in green leafy vegetables and beetroot. There is evidence that increased nitrate in your diet can improve the way that blood vessels function and make muscles work more efficiently. Beetroot juice drinks are a good source of nitrate. In a previous study, we showed that a single dose of a nitrate-rich beetroot drink enabled people with COPD who need to use oxygen to walk further. We now want to see if taking this drink regularly for a longer period of time can improve your daily experience of physical activity (how much you can do and how difficult it feels). This study will look at the effect of three months' use of a dietary beetroot juice drink with nitrate, compared to a dummy or placebo beetroot drink. The placebo beetroot drink looks and tastes the same as the beetroot drink, but the nitrate has been removed. We want to see if this will improve the experience of physical activity in people with COPD who need to use oxygen. We will also be looking to see if this improves other measurements such as exercise capacity and blood vessel function. If the study shows that this form of dietary supplementation improves the experience of physical activity, it might become part of the routine treatment for people with this condition.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Sep 2022 31 Jan 2025

Participants will be asked to attend three appointments at the Royal Brompton Hospital, two at the beginning of the study (1 week apart) and one at the end of the study 3 months later. The study visits will include a blood test, spirometry test, non-invasive blood vessel function test (EndoPAT test) and walk test. Outside of study visits, participants will be asked to wear a small activity monitor for a week at the beginning and end of the study. After the second visit participants will be randomised into two groups and each given small 70ml beetroot juice drinks to drink every day for 3 months. One group will have beetroot juice containing nitrate and one group will have beetroot juice which has had the nitrate removed, both drinks are identical in appearance and taste and neither the participant nor the researcher will know which group participants are in.


People with COPD who need to use supplemental oxygen

You can take part if:



You may not be able to take part if:


1. Inability to consent2. Systolic blood pressure below 120mmHg3. Exacerbation within the last four weeks4. Use of nitrate-based medication


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Brighton and Sussex University Hospitals NHS Trust
    Royal Sussex County Hospital Eastern Road
    Brighton
    BN2 5BE
  • Glenfield Hospital
    Groby Road
    Leicester
    LE3 9QP
  • Royal Brompton & Harefield NHS Foundation Trust
    Royal Brompton Hospital Sydney Street
    London
    SW3 6NP
  • Imperial College Healthcare NHS Trust
    The Bays St Marys Hospital South Wharf Road
    London
    W2 1BL
  • Kings College Hospital
    Mapother House De Crespigny Park Denmark Hill
    London
    SE5 8AB
  • Guys and St Thomas' NHS Foundation Trust
    249 Westminster Bridge Road
    London
    SE1 7EH

You may or may not benefit directly from this study, but the results may help doctors in the future treat people who have COPD and need to use oxygen. Most of the procedures in this study, such as the recording of your weight, height, hip, waist, body composition, wearing activity monitors and blood pressure present no risk to you. Other procedures, such as taking blood samples, can cause mild discomfort. The risks of taking a blood sample include slight discomfort when the needle is inserted and possible bruising or localised infection. These procedures will only be carried out by an experienced health professional under sterile conditions to minimise all these risks. There are also no major side effects associated with taking the beetroot juice drink. Some people find the taste unpleasant and occasionally experience mild stomach discomfort, but this usually settles down after a few days. Most people notice that their urine becomes darker or orangey-red, because of the natural red pigment in the beetroot juice.

Ms Alexis Perkins
None available
alexis.perkins20@imperial.ac.uk


Prof Nicholas Hopkinson
+44 (0)20 73497775
n.hopkinson@ic.ac.uk



The study is sponsored by Imperial College London and funded by National Institute for Health and Care Research Evaluation, Trials and Studies Co-ordinating Centre (NETSCC); Grant Codes: NIHR131548.



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Read full details for Trial ID: ISRCTN12474100

Or CPMS 53147

Last updated 18 December 2024

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