Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Roger Greenhalgh
+44 (0)208 846 7316
r.greenhalgh@imperial.ac.uk


Study Location:

Dept Vascular Surgery
London
W6 8RF


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Does angioplasty offer benefit over best medical treatment and supervised exercise training in mild to moderate intermittent claudication (MIMIC) patients?

Not Recruiting

Open to: All Genders

Age: Adult

Medical Conditions

Intermittent claudication
peripheral vascular disease


This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.




Not provided at time of registration

The aim of the MIMIC trials is to assess the adjuvant benefit of percutaneous transluminal angioplasty (PTA) in patients with Mild to Moderate Intermittent Claudication (MIMIC). All patients will receive best medical treatment, including advice to stop smoking and receive supervised exercise training for 6 months. 340 patients from 10 centres will be randomly allocated to receive angioplasty or not into one of two trials, one for aorto-iliac disease and another for femoro-popliteal disease and followed up for 2 years. It is expected that the MIMIC trials will show whether either aorto-iliac or femoro-popliteal angioplasty are of adjuvant benefit to best medical treatment and exercise therapy in terms of Absolute Walking Distance (AWD) as the primary endpoint, and secondly in terms of both specific and generic health related quality of life (HRQL) measures and, if beneficial, the cost effectiveness of the additional intervention.


Randomised controlled trial

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Feb 2003

31 Jan 2007

Publications

2008 Results article in http://www.ncbi.nlm.nih.gov/pubmed/19022184 results

Interventional

Intervention Type : Other
Intervention Description : Supervised exercise therapy versus supervised exercise therapy and PTA.


You can take part if:


1. Patients with stable mild to moderate intermittent claudication2. Patients satisfying the criteria of the Edinburgh Claudication Questionnaire3. Patients suitable for aorto-iliac or femoro-popliteal PTA after duplex mapping or diagnostic arteriography4. Ankle Brachial Pressure Indices (ABPI) <0.9 or >0.9 with a positive stress test i.e. a fall of >30 mmHg following a treadmill test at 4 km/h, 10 degree slope for 1 min




You may not be able to take part if:

1. Patients with intermittent claudication too mild for patient or doctor to consider PTA2. Patients with intermittent claudication severe enough to merit consideration of bypass surgery3. Patients with critical ischaemia i.e. absolute Doppler pressure <50 mmHg, or presence of ulcers or gangrene with a Doppler pressure >50 mmHg4. Patients with ankle/brachial pressure index (ABPI) >0.9 with a negative stress test who could have sciatica or very mild peripheral arterial disease (insignificant arterial disease)5. Patients with musculoskeletal, cardiac or any other concomitant disease that renders consideration for supervised exercise inappropriate


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Dept Vascular Surgery
    London
    W6 8RF


The study is sponsored by Imperial College London (UK) and funded by Camelia Botnar Arterial Research Foundation (UK); Bard Ltd (UK); Boston Scientific Ltd (UK); Cook UK Ltd (UK).



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for Trial ID: ISRCTN37194085

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