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Contact Information:

James Ware 0330 128 2294
go-dcm@imperial.ac.uk


Chief Investigator 0330 128 2294
go-dcm@imperial.ac.uk


Study Location:

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Be Part of Research - Trial Details - Defining the Genetics, Biomarkers and Outcomes for Dilated Cardiomyopathy

Defining the Genetics, Biomarkers and Outcomes for Dilated Cardiomyopathy

Recruiting

Open to: ALL

Age: N/A - 99.0

Medical Conditions

Cardiovascular Diseases
Cardiomyopathies
Cardiomyopathy, Dilated


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Finding new ways to diagnose and treat Dilated Cardiomyopathy (DCM) could improve the health and well-being of patients with this condition. The main aim of this research study is to help develop better ways of diagnosing and treating patients with DCM. The information that is collected may help develop tailored treatments for patients with this disease in the future. This research study will recruit patients with DCM from a number of centres across England and follow their health over a period of years. Patients will give some blood samples for a type of genetic test called whole genome sequencing (WGS) to look for genetic changes. Patients will also have a magnetic resonance imaging (MRI) scan of their heart to look for any changes in the heart such as scarring, and check their heart function. The aim of this study is to discover if using WGS and MRI can improve the diagnosis of DCM. Another aim of the study is to look at how genetic changes and scarring in the heart may affect the progress of the disease.

Studying patients with DCM may also help the investigators learn more about diagnosing and treating other diseases of the heart. The second aim of this study is to see whether using WGS and MRI scanning can also be useful in other types of heart diseases which might be affected by genetic changes or scarring in the heart.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jan 2020 Jul 2027

OBSERVATIONAL

Intervention Type : OTHER
Intervention Description : Patients with a confirmed diagnosis of DCM will have samples that undergo whole genome sequencing and biomarker analysis

Intervention Arm Group : Part 1: Dilated Cardiomyopathy patients;

Intervention Type : OTHER
Intervention Description : Biomarker analysis will be undertaken on samples

Intervention Arm Group : Part 2: Heritable Cardiovascular Disease;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Glenfield Hospital
    Leicester
    LE3 9QP
  • Southampton General Hospital
    Southampton
    SO16 6YD
  • Liverpool Heart and Chest Hospital NHS Foundation Trust
    Liverpool
    L14 3PE
  • Leeds Teaching Hospitals NHS Trust
    Leeds
    LS1 3EX
  • Royal Brompton & Harefield NHS Foundation Trust
    London
    SW3 6NP
  • Oxford University Hospitals NHS Foundation Trust
    Oxford


The study is sponsored by Imperial College London and is in collaboration with British Heart Foundation; Royal Brompton & Harefield NHS Foundation Trust.




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Read full details for Trial ID: NCT03843255
Last updated 29 March 2022

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