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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

IDEAYA Clinical Trials 1 650-534-3616
IDEAYAClinicalTrials@ideayabio.com


Hetal Patel, MD, MSHS, CHCQM 650-741-3856
hpatel@ideayabio.com


Study Location:

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English | Cymraeg
Be Part of Research - Trial Details - IDE196 (Darovasertib) in Combination with Crizotinib As First-line Therapy in Metastatic Uveal Melanoma

IDE196 (Darovasertib) in Combination with Crizotinib As First-line Therapy in Metastatic Uveal Melanoma

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Melanoma
Uveal Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a Phase 2/3, multi-arm, multi-stage, open-label study of human leukocyte antigen (HLA)-A\*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotinib or investigator's choice of treatment (pembrolizumab, ipilimumab + nivolumab, or dacarbazine).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Oct 2023 Jan 2027

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Dosed orally, twice daily

Intervention Arm Group : Phase 2a Dose Optimization of IDE196 + crizotinib;Phase 2b / 3 Chosen Combination dose of IDE196 + crizotinib;

Intervention Type : DRUG
Intervention Description : Dosed orally, twice daily

Intervention Arm Group : Phase 2a Dose Optimization of IDE196 + crizotinib;Phase 2b / 3 Chosen Combination dose of IDE196 + crizotinib;

Intervention Type : DRUG
Intervention Description : IV administration every 3 weeks

Intervention Arm Group : Phase 2a / 2b / 3 Comparator Arm;

Intervention Type : DRUG
Intervention Description : IV administration every 3 weeks for 4 Cycles

Intervention Arm Group : Phase 2a / 2b / 3 Comparator Arm;

Intervention Type : DRUG
Intervention Description : IV administration every 3 Weeks for 4 Cycles, thereafter every 4 Weeks maintenance

Intervention Arm Group : Phase 2a / 2b / 3 Comparator Arm;

Intervention Type : DRUG
Intervention Description : IV administration every 3 Weeks

Intervention Arm Group : Phase 2a / 2b / 3 Comparator Arm;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Beatson West of Scotland Cancer Centre
    Glasgow
    G12 0YN
  • The Clatterbridge Cancer Centre NHS Foundation Trust
    Wirral
    CH63 4JY
  • Mount Vernon Cancer Centre East & North Herts NHS Trust
    Northwood
    HA6 2RN

IDEAYA Clinical Trials 1 650-534-3616
IDEAYAClinicalTrials@ideayabio.com


Hetal Patel, MD, MSHS, CHCQM 650-741-3856
hpatel@ideayabio.com



The study is sponsored by IDEAYA Biosciences




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Read full details for Trial ID: NCT05987332
Last updated 25 March 2025

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