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Be Part of Research - Trial Details - A Study to Evaluate the Efficacy and Safety of MABT5102A in Patients With Mild to Moderate Alzheimer's Disease (ABBY)

A Study to Evaluate the Efficacy and Safety of MABT5102A in Patients With Mild to Moderate Alzheimer's Disease (ABBY)

Completed

Open to: ALL

Age: 50.0 - 80.0

Medical Conditions

Alzheimer Disease


This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


This is a Phase II, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the safety and efficacy of MABT5102A in patients with mild to moderate Alzheimer's Disease.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Apr 2011 Feb 2014

Publications

"Yoshida K, Moein A, Bittner T, Ostrowitzki S, Lin H, Honigberg L, Jin JY, Quartino A. Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer's disease. Alzheimers Res Ther. 2020 Jan 22;12(1):16. doi: 10.1186/s13195-020-0580-2."; "31969177"

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Repeating subcutaneous injection

Intervention Arm Group : Part 1: Subcutaneous cohort exp;

Intervention Type : DRUG
Intervention Description : Repeating intravenous infusion

Intervention Arm Group : Part 2: Intravenous cohort exp;

Intervention Type : DRUG
Intervention Description : Repeating subcutaneous injection

Intervention Arm Group : Part 1: Subcutaneous cohort;

Intervention Type : DRUG
Intervention Description : Repeating intravenous infusion

Intervention Arm Group : Part 2: Intravenous cohort;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Rice Centre; Royal United Hospital
    Bath
    BA1 3NG
  • West London Research Unit; Brentford Lodge
    Brentford
    TW8 8DS
  • Royal Sussex County Hospital, CIRU Level 5
    Brighton
    BN2 5BE
  • Glasgow Memory Clinic
    Glasgow
    G20 0XA
  • The National Hospital for Neurology & Neurosurgery; Dementia Research Center
    London, GT LON
    WC1N 3BG
  • Camden Mews Day Hospital; Camden and Islington
    London
    NW1 9DB
  • Southampton General Hospital; Pharmacy
    Southampton
    SO16 6YD
  • Moorgreen Hospital; Memory Assessment & Rsch Ctr
    Southampton
    SO30 3JB
  • Great Western Hosp.; Kingshill Research Ctr
    Swindon
    SN3 6BW


The study is sponsored by Genentech, Inc.




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Read full details for Trial ID: NCT01343966
Last updated 10 July 2017

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