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Be Part of Research - Trial Details - Study of Ibrutinib Combined With Venetoclax in Subjects With Mantle Cell Lymphoma (SYMPATICO)

Study of Ibrutinib Combined With Venetoclax in Subjects With Mantle Cell Lymphoma (SYMPATICO)

Completed

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Lymphoma
Lymphoma, Mantle-Cell


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This Phase 3 multinational, randomized, double-blind study is designed to compare the efficacy and safety of the combination of ibrutinib and venetoclax vs. ibrutinib and placebo in subjects with MCL.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jun 2017 Jun 2024

Publications

"Wang M, Ramchandren R, Chen R, Karlin L, Chong G, Jurczak W, Wu KL, Bishton M, Collins GP, Eliadis P, Peyrade F, Lee Y, Eckert K, Neuenburg JK, Tam CS. Concurrent ibrutinib plus venetoclax in relapsed/refractory mantle cell lymphoma: the safety run-in of the phase 3 SYMPATICO study. J Hematol Oncol. 2021 Oct 30;14(1):179. doi: 10.1186/s13045-021-01188-x."; "34717692"

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Administered orally once daily

Intervention Arm Group : Phase 3: Ibrutinb + Venetoclax;Phase 3: Ibrutinib + Placebo;Safety Run-in Period;Treatment-naive;

Intervention Type : DRUG
Intervention Description : Administered orally once daily

Intervention Arm Group : Phase 3: Ibrutinb + Venetoclax;Safety Run-in Period;Treatment-naive;

Intervention Type : DRUG
Intervention Description : Administered orally once daily

Intervention Arm Group : Phase 3: Ibrutinib + Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Royal Marsden NHS Foundation Trust
    Sutton
    Surrey
    SM2 5PT
  • The Christie NHS Foundation Trust
    Manchester
    Greater Manchester
    M20 4BX
  • Nottingham University Hospitals NHS Trust
    Nottingham
    Nottinghamshire
    NG5 1PB
  • Barts Health NHS Trust
    London
    Greater London
    EC1A 7BE
  • The Churchill Hospital
    Oxford
    Oxfordshire
    OX3 7LE
  • St James University Hospital
    Leeds
    West Yorkshire
    LS9 7TF
  • University College London Hospitals NHS Foundation Trust
    London
    NW1 2PG


The study is sponsored by Pharmacyclics LLC. and is in collaboration with Janssen Research & Development, LLC.




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Read full details for Trial ID: NCT03112174
Last updated 28 June 2024

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