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Be Part of Research - Trial Details - Study of ALXN2050 in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)

Study of ALXN2050 in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)

Stopped

Open to: ALL

Age: 18.0 - 75.0

Medical Conditions

Kidney Diseases
Nephritis
Lupus Nephritis
Glomerulonephritis, IGA


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study of ALXN2050 (120 and 180 milligrams \[mg\]) in addition to background therapy consistent with the standard of care in adult participants (≥ 18 to ≤ 75 years of age) with either LN or IgAN. The study will consist of an up to 6-week Screening Period, a 26-week blinded Initial Evaluation Period, a 24-week blinded Extended Treatment Period, and an Open-label Extension (OLE) Period of up to 2 years.

Safety will be monitored throughout the study.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jan 2022 Dec 2024

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Oral tablets

Intervention Arm Group : IgAN Cohort: ALXN2050 120 mg;IgAN Cohort: ALXN2050 180 mg;LN Cohort: ALXN2050 120 mg;LN Cohort: ALXN2050 180 mg;

Intervention Type : DRUG
Intervention Description : Oral tablets

Intervention Arm Group : IgAN Cohort: Placebo;LN Cohort: Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    Bristol
    BS105NB
  • Research Site
    London
    E1 1BB
  • Research Site
    Cambridge
    CB2 0QQ
  • Research Site
    London
    SE5 9RS
  • Research Site
    Manchester
    M13 9WL
  • Research Site
    London
    SE1 9RT
  • Research Site
    London
    SM5 1AA
  • Research Site
    Doncaster
    DN2 5LT
  • Research Site
    Leicester
    LE5 4PW
  • Research Site
    Newcastle upon Tyne
    NE7 7DN


The study is sponsored by Alexion Pharmaceuticals, Inc.





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Read full details for Trial ID: NCT05097989
Last updated 26 March 2025

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