We'd like your feedback
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Miss
Suzanne
Carter
+44 (0)1617016941
suzanne.carter@manchester.ac.uk
Prof
Emma
Crosbie
+44 (0)1617016942
emma.crosbie@manchester.ac.uk
Identification of cervical cancer risk in women over 65 years of age using urine HPV testing
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Cervical screening can save lives from cervical cancer, yet only 7 in 10 women in the UK attend screening, the lowest rate in 20 years. Reasons include embarrassment, fear of speculum examination and inconvenience. Poor attendance is highest amongst women at greatest risk of cervical cancer, including smokers from socio-economically deprived backgrounds. Cervical screening is offered to women aged 25-65 years in the UK, stopping at 65 years partly for historical reasons and partly because speculum examination is uncomfortable for elderly women. Yet deaths from cervical cancer are highest amongst women aged over 70 years, particularly those who haven’t attended cervical screening previously. For these reasons, several countries across Europe and Australia have now extended their cervical screening programmes to women aged up to 79 years.
Cervical screening is carried out by collecting cells from the cervix (neck of the womb) with a soft brush. These cells are tested for a virus known to cause cancer called human papillomavirus (HPV). If HPV is detected, the cells are examined under the microscope. If they look abnormal, the woman is referred to a colposcopy clinic, where cells that are
found to be ‘pre-cancerous’ (cells with the potential to become cancer cells) are identified and treated. To increase screening rates, vaginal ‘self-sampling’ has been tried, where a woman collects cells from her vagina at home and returns the sample by post, but only 1 in 10 women return the sample. There is therefore an urgent need for new ways to reverse declining rates of cervical screening.
Researchers are developing a urine test that can detect HPV. This test has the potential to remove many of the current barriers to screening and could substantially increase the number of women attending. This study will offer a urine HPV test to women or people with a cervix aged 65 years and older who have exited the cervical screening programme and are attending a Manchester University NHS Foundation Trust (MFT) community-based lung cancer screening service for current and ex-smokers. It will find out whether a one-stop-shop that combines cervical and lung screening is feasible; whether urine HPV testing encourages high-risk non-attenders from underserved communities to be screened; and whether the prevalence of HPV in women aged over 65 years justifies a reappraisal of arbitrary, non-evidence-based age cut-offs for cervical screening.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
You may not be able to take part if:
1. Previous total hysterectomy (no cervix)2. Unable to provide a urine sample3. Unable to understand the Patient Information Sheet and consent form4. Any condition that would compromise participant safety or data integrity
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Miss
Suzanne
Carter
+44 (0)1617016941
suzanne.carter@manchester.ac.uk
Prof
Emma
Crosbie
+44 (0)1617016942
emma.crosbie@manchester.ac.uk
The study is sponsored by University of Manchester and funded by Manchester Academic Health Science Centre.
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Or CPMS 51689
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
