Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Alex Hainsworth +44(0)121 414 2535
mithridate@trials.bham.ac.uk


Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polycythemia Vera

MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polycythemia Vera

Medical Conditions

Polycythemia Vera
Polycythemia


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The trial will be a phase III, randomised-controlled, multi-centre, international, open-label trial consisting of ruxolitinib versus best available therapy, where best available therapy is a choice of interferon alpha, any formulation permitted (IFN) or hydroxycarbamide (HC), and which will be elected by the Investigator prior to randomisation.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Oct 2019 Oct 2028

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : 10mg of ruxolitinib twice daily (bd)

Intervention Arm Group : A- Ruxolitinib;

Intervention Type : DRUG
Intervention Description : Via standard hospital mechanisms

Intervention Arm Group : B- Hydroxycarbamide OR Interferon A;

Intervention Type : DRUG
Intervention Description : Any formulation, via standard hospital mechanisms

Intervention Arm Group : B- Hydroxycarbamide OR Interferon A;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Russells Hall Hospital
    Dudley
    DY1 2HQ
  • Gloucestershire Royal Hospital
    Gloucester
    GL1 3NN
  • St George's Hospital
    London
    SW17 0QT
  • Blackpool Victoria Hospital
    Blackpool
    FY3 8NR
  • Kettering General Hospital
    Kettering
    NN16 8UZ
  • New Cross Hospital
    Wolverhampton
    WV10 0QP
  • Royal Bournemouth Hospital
    Bournemouth
    BH7 7DW
  • Southampton General Hospital
    Southampton
    SO16 6YD
  • Sunderland Royal Hospital
    Sunderland
    SR4 7TP
  • The James Cook University Hospital
    Middlesbrough
    TS4 3BW
  • Worthing Hospital
    Worthing
    BN11 2DH
  • Birmingham Heartlands Hospital
    Birmingham
    B9 5SS
  • Royal Gwent Hospital
    Newport
    NP20 2UB
  • Belfast City Hospital
    Belfast
    BT9 7AB
  • Nottingham City Hospital
    Nottingham
    NG5 1PB
  • University College Hospital
    London
    NW1 2BU
  • Southmead Hospital
    Bristol
    BS10 5NB
  • Raigmore Hospital
    Inverness
    IV2 3UJ
  • Royal Berkshire Hospital
    Reading
    RG1 5AN
  • Royal Devon and Exeter Hospital
    Exeter
    EX2 5DW
  • Western General Hospital
    Edinburgh
    EH4 2XU
  • Leicester Royal Infirmary
    Leicester
    LE1 5WW
  • Wythenshawe Hospital
    Manchester
    M23 9LT
  • Warwick Hospital
    Warwick
    CV34 5BW
  • Norfolk and Norwich University Hospital
    Norwich
    NR4 7UY
  • University Hospital of Wales
    Cardiff
    CF14 4XW
  • Guy's Hospital
    London
    SE1 9RT
  • Royal United Hospital
    Bath
    BA1 3NG
  • Aberdeen Royal Infirmary
    Aberdeen
    AB25 2ZN
  • Castle Hill Hospital
    Cottingham
    HU16 5JQ
  • Huddersfield Royal Infirmary
    Huddersfield
    HD3 3EA
  • Northampton General Hospital
    Northampton
    NN1 5BD
  • Arrowe Park Hospital
    Wirral
    CH49 5PE
  • Calderdale Royal Hospital
    Halifax
    HX3 0PW
  • Royal Cornwall Hospital
    Truro
    TR1 3LJ
  • Wexham Park Hospital
    Slough
    SL2 4HL
  • Kent and Canterbury Hospital
    Canterbury
    CT1 3NG
  • St John's Hospital
    Livingston
    EH54 6PP
  • St Richard's Hospital
    Chichester
    PO19 6SE
  • Colchester Hospital
    Colchester
    CO4 5JL
  • Good Hope Hospital
    Sutton Coldfield
    B75 7RR
  • Addenbrooke's Hospital
    Cambridge
    CB2 0QQ
  • Freeman Hospital
    Newcastle Upon Tyne
    NE7 7DN
  • North Tyneside General Hospital
    North Shields
    NE29 8NH
  • Churchill Hospital
    Oxford
    OX3 7LE
  • Halton Hospital
    Runcorn
    WA7 2DA
  • Royal Stoke University Hospital
    Stoke-on-Trent
    ST4 6QG


The study is sponsored by University of Birmingham and is in collaboration with Novartis; MPN Voice; French National Cancer Institute (Institut National Du Cancer - France).




We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: NCT04116502
Last updated 13 November 2024

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.