Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Rohini Sharma, Professor 02083833170
rohini.sharma2@nhs.net


Study Location:

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Be Part of Research - Trial Details - Lutathera and ASTX727 in Neuroendocrine Tumours

Lutathera and ASTX727 in Neuroendocrine Tumours

Recruiting

Open to: ALL

Age: 18.0 - 99.0

Medical Conditions

Neuroendocrine Tumors


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Patients entered into the study will receive ASTX727 orally for 5 days, prior to receiving Lutathera treatment on Day 8, to determine whether pre-treatment with ASTX727 results in re-expression of somatostatin receptor-2 in patients with metastatic neuroendocrine tumours. The study will use \[68Ga\]-DOTA-TATE PET to image epigenetic modification of the receptor locus.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Apr 2022 Dec 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Cedazuridine 100mg + 35mg decitabine

Intervention Arm Group : Treatment;

Intervention Type : RADIATION
Intervention Description : Peptide receptor radionuclide therapy (PRRT)

Intervention Arm Group : Treatment;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Hammersmith Hospital
    London
    London, City of
    W12 0HS

Rohini Sharma, Professor 02083833170
rohini.sharma2@nhs.net



The study is sponsored by Imperial College London and is in collaboration with Advanced Accelerator Applications International SA.




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Read full details for Trial ID: NCT05178693
Last updated 01 May 2025

This page is to help you find out about a research study and if you may be able to take part

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