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Be Part of Research - Trial Details - The Effect of a SGLT2 Inhibitor on Glucose Flux, Lipolysis and Exercise in Type 2 Diabetes

The Effect of a SGLT2 Inhibitor on Glucose Flux, Lipolysis and Exercise in Type 2 Diabetes

Completed

Open to: ALL

Age: 18.0 - 75.0

Medical Conditions

Diabetes Mellitus
Diabetes Mellitus, Type 2


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The study is a randomised double blind placebo control cross over trial with 4 weeks washout period. The expected duration of participant participation is 103 days. the study aims to investigate the effect of dapagliflozin, a SGLT2 inhibitor, on glucose flux, lipolysis and exercise in patients with type 2 diabetes.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2018 Jan 2020

Publications

"Herring RA, Shojaee-Moradie F, Stevenage M, Parsons I, Jackson N, Mendis J, Middleton B, Umpleby AM, Fielding BA, Davies M, Russell-Jones DL. The SGLT2 Inhibitor Dapagliflozin Increases the Oxidation of Ingested Fatty Acids to Ketones in Type 2 Diabetes. Diabetes Care. 2022 Jun 2;45(6):1408-1415. doi: 10.2337/dc21-2043."; "35312749"

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Dapagliflozin 10 MG

Intervention Arm Group : Dapagliflozin;

Intervention Type : DRUG
Intervention Description : Matching placebo tablets

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • CEDAR, Royal Surrey County Hospital
    Guildford
    Surrey
    GU2 7XX


The study is sponsored by University of Leicester and is in collaboration with Royal Surrey County Hospital NHS Foundation Trust; AstraZeneca.





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Read full details for Trial ID: NCT04219124
Last updated 26 April 2021

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