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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Disorders of sclera, cornea, iris and ciliary bodyInflammatory polyarthropathies
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This study will compare imaging-based eye checks to routine clinical checking for uveitis in children with juvenile idiopathic arthritis (JIA) in order to support the design of a future study.
Childhood uveitis is a potentially blinding eye disease. Half of all children with uveitis also have a joint disorder: juvenile idiopathic arthritis (or JIA). Children with JIA must travel to a specialist centre every three months to have eye examinations in an attempt to pick uveitis up early enough to prevent visual loss. Delays in picking up uveitis are the commonest cause of visual loss in children.
Currently, 73% of consultant ophthalmology posts are unfilled. There are local reports of long delays in diagnosis of uveitis due to challenges in accessing specialist care. In these cases uveitis is only detected in children after symptomatic presentation with visual loss subsequent to untreated eye inflammation. Effective use of imaging modalities (particularly a modality currently in use for adult disease across high street opticians in the UK) would support wider accessibility to uveitis surveillance for children at risk of uveitis.
Optical coherence tomography (OCT) is a non-contact non-irradiating imaging modality. We have recently demonstrated that OCT for uveitis detection in children is possible, acceptable to families, repeatable, sensitive, and specific. Our team has developed protocols for taking and analysing images of the eyes of children with uveitis.
We shall be undertaking a feasibility study which compares routine clinical examination based uveitis surveillance to imaging based surveillance. It is a feasibility study because it will generate useful information to help us plan a larger scale clinical trial of imaging based uveitis surveillance in children. of clinical and cost-effectiveness. Following informed consent, children aged 2 – 12 years old who have recently been diagnosed with JIA will be randomised to undergo uveitis surveillance with either slit lamp examination (standard care) or OCT imaging over a one year period. At study end, a subset of participants will also be invited to take part in interviews to understand barrier and facilitators of study participation (recruitment and avoidance of attrition). We shall also undertake surveys of professionals to understand barrier and facilitators of later up take of this new use for eye imaging.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Interventional type: Imaging;Active Monitoring;
You can take part if:
You may not be able to take part if:
- A previous / existing diagnosis of uveitis - Ocular co-morbidities that would affect vision - Developmental/learning difficulties that preclude concordance with examination / informed assent
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by UCL Great Ormond Street Institute of Child Health and funded by FIGHT FOR SIGHT .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 58914
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