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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Other forms of heart disease
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Heart failure is a complex condition which affects the hearts’ ability to pump blood around the body properly. Due to this complexity, it often affects multiple systems in the body and can impact the quality of life. A proportion of heart failure patients also have muscle weakness, where one can feel fatigued, and weak, and may have trouble balancing and standing. To characterise muscle weakness, it is important to look at skeletal muscle mass, strength, and function.
The study will focus on the prevalence of reduced muscle strength or function, using a variety of assessments within patients with heart failure. The prevalence of muscle weakness will be investigated by running assessments to look into muscle strength, we will run a series of simple exercise tests of the calf and thigh, in addition to a walking test, a balance test and a standing test to assess whole body performance. To look at the quality of skeletal muscle, a magnetic resonance imaging (MRI) and spectroscopy session will allow us to investigate the quality of the thigh muscle and the energetics in the calf. Finally, a muscle biopsy will be performed to understand differences in muscle tissue in people with different types of heart failure.
Overall, this study will provide us with unique information on skeletal muscle strength, composition and energetics within patients with heart failure, by looking at the main factors which characterise muscle weakness.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
HF Patients 1. Absolute contraindication to MRI 2. Inability to walk/undertake the 6MWT. 3. Neuromuscular disorders that may impact skeletal muscle assessment, such as motor neurone disease, multiple sclerosis, skeletal muscle myopathies and myositis 4. Regular or intermittent oral corticosteroid use 5. Untreated hyper or hypo-thyroidism Exclusion criteria for healthy volunteers 1. Previous or current signs of HF 2. Risk factors for devlopment of HF, such as hypertension, diabetes Mellitus or known coronary artery disease Asymptomatic T2D Controls 1. Angina pectoris or limiting dyspnoea (> NYHA II), 2. Major atherosclerotic disease: Symptomatic CAD, history of MI, previous revascularisation, stroke/transient ischaemic attack or symptomatic peripheral vascular disease. 3. Atrial fibrillation or flutter. 4. Moderate or severe valvular heart disease. 5. History of heart failure or cardiomyopathy. 6. Type 1 diabetes mellitus (T1DM). 7. Low fasting C-peptide levels suggestive of adult-onset T1DM. 8. Stage III-V renal disease (estimated glomerular filtration rate < = 30ml/min/1.73m2). 9. Absolute contraindications to CMR.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of Leicester and funded by BRITISH HEART FOUNDATION .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 57495
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