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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Disorders related to length of gestation and fetal growthOedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperiumOther maternal disorders predominantly related to pregnancy
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Every expectant parent anticipates having a healthy pregnancy and baby, but sadly many pregnancies are affected by conditions such as preterm birth (PTB), preeclampsia, gestational diabetes, or a low birthweight/small for gestational age (SGA) infant. To gain greater insight into the biological mechanisms and maternal exposures that result in such pregnancy complications, there is a need to understand how complications deviate from the normal trajectory of a healthy pregnancy. Also, knowing how maternal exposures and health (pre-pregnancy and during pregnancy) and alterations in the pregnancy environment can impact on in utero fetal wellbeing and subsequent maternal, infant and child health is key if we are to develop prediction tools, preventative therapies and treatments that benefit both the mother and child.
INSIGHT-2 will recruit women from the general antenatal population and women of known higher risk for pregnancy complications such as PTB, hypertensive disorders, poor fetal growth, and gestational diabetes. We will also target women whose pregnancies have a risk factor (e.g., diabetes, obesity, metabolic syndrome, autoimmune disorders, and eczema/atopy/asthma) for later child health problems.
Through the collection of a comprehensive set of biological samples and clinical data in this cohort, we aim to explore pre-pregnancy and pregnancy factors that may contribute to disease processes and impact on fetal wellbeing and future health. This will provide a comprehensive picture of disease mechanisms in both the mother and child, aid identification of biomarkers for prediction, diagnosis and management of pregnancy complications. In addition, it will provide a valuable longitudinal study of the relationship between the in utero environment, pregnancy management and outcomes and future maternal and child health.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
• Age of the mother < 16 years old. • Inability to consent. • Known significant congenital or structural or chromosomal fetal abnormality.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by GUY'S AND ST THOMAS' NHS FOUNDATION TRUST and funded by THE BORNE FOUNDATION; THE LEONA AND HARRY B HELMSLEY FOUNDATION INC; .
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Read full details
for Trial ID: CPMS 57420
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