We'd like your feedback
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Natasha
Corballis
Natasha.corballis@nnuh.nhs.uk
Vassilios
Vassiliou
v.vassiliou@uea.ac.uk
Ischaemic heart diseases
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
The coronary arteries are the blood vessels that supply oxygenated blood to the heart muscle, allowing it to pump. When these vessels narrow or block, this can cause angina or heart attacks. This is usually treated with drug eluting stents (a metal scaffold inserted into the vessel). 1 in 5 of these occur at the site of a bifurcation (where the blood vessels branch into two vessels). Treating bifurcations is more challenging and can cause more complications. An alternative way to treat this is a drug coated balloon. This is a special type of balloon that is inflated in the blood vessel. The drug coating on the balloon touches the side of the vessel and this is absorbed into the vessel wall. The balloon is removed so no scaffold is left behind in the vessel. These balloons are recommended for use within a re-narrowed stent or a small vessel narrowing.
We intend to look at drug coated balloons and drug eluting stents in a novel way in a bifurcation narrowing using advanced ways of imaging the vessel. This will generate computer models of blood flow to see if blood flow is more normal in the vessel without the stent in. The way that we do this is by analysing the flow at the initial procedure and then bringing these patients back at 3-6 months to re-assess the blood flow. We will use additional measurements:
1. The size of both branches of the vessel initially and at 3-6 months
2. Flow down the vessel using a special wire after the procedure and at 3-6 months to see if there is any difference between using drug eluting stents or drug coated balloons
3. Presence of angina at 12 months using a questionnaire
We intend to do this for 24 patients.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Type: Active Monitoring;
You can take part if:
You may not be able to take part if:
- Cardiogenic shock - LVEF < 30% - STEMI (as unable to give informed consent prior to procedure) - eGFR < 30 - Severe asthma contra-indicating the use of adenosine - High degree AV block on 12 lead ECG precluding the use of adenosine - Pregnancy - Inability to consent - Left main stem coronary bifurcation lesions
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of East Anglia and funded by NIHR Academy .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 56807
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
