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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Other respiratory diseases principally affecting the interstitium
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This cohort study aims to assess the microbiome (the community of bacteria) of the gut and oral cavity of healthy volunteers. This will allow us to compare these communities to those of patients with interstitial lung disease (ILD), who are thought to have a disordered microbiome. If we find differences between the microbiome between healthy volunteers and ILD patients, it may facilitate earlier diagnosis from screening tests or even for potential targets for treatment.
This study will be run from the Royal Brompton Hospital. Participants will be recruited from the general population and will be offered £25 per study visit. Any individual between the age of 18-99 without a history of respiratory disease is eligible for participation. Smokers and ex-smokers are eligible as long as they have no current respiratory condition. The study aims to collect oral and stool samples at baseline, and at 3 and 12 months after the initial visit. It is therefore anticipated that samples collection will take up to two years. Participants will be sent collection kits in the post with stamped return packages so will not need to attend the hospital. Samples will be analysed to assess the types of bacteria present.
A full medical history will be obtained to establish whether participants have any history of respiratory disease, take any medications or have any diagnoses that may alter the microbiome. At each sampling point a repeat medical history will be taken and participants will be sent an online questionnaire including a three-day food diary and food frequency questionnaire.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
Exclusion criteria include a history of respiratory disease and known confounders of the gastrointestinal and oral microbiome. These include antibiotic use in the preceding three months, inflammatory or infectious diseases, and a history of gastrointestinal disease including malignancy or surgery.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by Imperial College of Science, Technology and Medicine and funded by ACTION FOR PULMONARY FIBROSIS .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 56432
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