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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
kate
duhig
Kate.duhig@manchester.ac.uk
kate
duhig
Kate.duhig@manchester.ac.uk
Javairia
Khalid
javairia.khalid@manchester.ac.uk
Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
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What is the aim of this study?
To develop new magnetic resonance imaging (MRI) techniques that can help improve the assessment of heart and placental function in pregnant women with high blood pressure and other risk factors for placental disease.
Why is this study important?
One in ten women have high blood pressure in pregnancy. Without treatment this can cause damage to a woman’s heart, kidneys and brain, and cause harm to her baby. It is likely that there are different pathways through which a woman develops high blood pressure in pregnancy. Some women remain well but their placenta can be affected causing the baby to be born very small. Other women have a baby with normal growth, but they themselves can develop severe problems their heart, kidneys and liver. There haven’t been enough studies to know which is the best blood pressure medicine to use in pregnancy. Previous studies have shown that the medicines commonly used do not work well in all women, but we don't fully understand why.
Over the last 25 years, MRI has proved a useful tool in assessing the heart, and is now the 'gold standard' for assessing it's function in adults, giving detailed insight in to the way the heart works and the impact of treatments for heart disease. Placental MRI has been developed over the last decade, and can give information about the way the placenta is functioning. This new study will aim to address the knowledge gap surrounding the pathways to developing and the treatment of blood pressure problems in pregnancy using MRI scanning of the heart and placenta.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
Exclusion criteria for the DAPHNE study includes: BMI > 50 claustrophobia pacemakers, metal implants or objects (e.g. aneurysm clips) participant age < 16 years those who, for reasons of language or learning difficulty, are unable to give informed consent known chromosomal or structural abnormality in the fetus multiple pregnancy
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Javairia
Khalid
javairia.khalid@manchester.ac.uk
kate
duhig
Kate.duhig@manchester.ac.uk
kate
duhig
Kate.duhig@manchester.ac.uk
The study is sponsored by University of Manchester and funded by ACADEMY OF MEDICAL SCIENCES .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 53386
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