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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Katherine
Baker
katherine.baker@northumbria.ac.uk
Jenni
Naisby
jenni.naisby@northumbria.ac.uk
Katherine
Baker
katherine.baker@northumbria.ac.uk
Extrapyramidal and movement disorders
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Up to 85% of people with Parkinson’s experience pain. Despite this, there has not been much research on pain in Parkinson's and how this behaves over time. No longitudinal studies have focused primarily on pain in Parkinson’s. Different types of pain and links with other Parkinson’s symptoms have not been assessed at different time points within the same population.
The largest study of pain (the Parkinson’s pain study) focuses on a population with early-stage Parkinson’s. We aim to follow up this population to explore the changes in types of pain over time and relationship with other symptoms at a later disease point.
The primary aim of this study is to increase our understanding of pain in Parkinson's over time using the Parkinson’s pain study data and data collected from this follow up.
We also aim to explore how pain in Parkinson’s relates to other symptoms.
This study is a follow up to the Parkinson’s Pain study. This will run alongside two separate studies: the Proband study, and the Oxford Monument Discovery Study. Both the Proband study and the Oxford Discovery Study are already running and have been given favourable ethical approval. These are two of the world’s largest ever in depth studies of people with Parkinson's. All patients in the these studies will have detailed assessments of their Parkinson's disease symptoms, as well as having blood samples taken to identify biomarkers.
The Proband study and the Oxford Discovery study are not investigating pain in Parkinson's. However these studies were always meant to encourage people to add other studies onto it. We want to add a brief (20 minute) assessment of pain. We will be able to combine the information from our study with the other detailed assessments in these studies to help us understand pain in Parkinson's.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
These are the Exclusion criteria of the Proband Study. 1) Patient has severe comorbid illness that would prevent full study participation 2) Patient has features indicating another type of degenerative parkinsonism, e.g. progressive supranuclear palsy 3)Druginduced parkinsonism (Drug unmasked PD is allowed) 4)Symmetrical lower body parkinsonism attributable to significant cortical and/or subcortical cerebrovascular disease (patients with ‘incidental’ small vessel disease on brain imaging are allowed). 5)Negative or normal functional imaging of the presynaptic dopamine system. 6)The presence of UK Brain Bank exclusion criteria will be recorded at baseline, allowing for the presence of 1 or 2 exclusion criteria (e.g. dopamine antagonist Drug used; more than one affected relative) (if justified e.g. by abnormal SPECT). These are the Exclusion criteria of the Oxford Monument Discovery Study. 1) Inability to provide informed consent or withdrawal of consent at any stage. Medical or psychiatric illness that would interfere with completing initial or followup assessments 2) Severe mental impairment due to dementia or psychosis 3) Pregnancy 4) Contraindication to lumbar puncture e.g. bleeding diathesis, epidural abscess, suspicion of raised intracranial pressure. 5) Contraindication to MRI e.g. incompatible metal foreign body or suspicion of such. 6)Contraindication to saccadometry e.g. double vision or serious eye disease
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Katherine
Baker
katherine.baker@northumbria.ac.uk
Jenni
Naisby
jenni.naisby@northumbria.ac.uk
Katherine
Baker
katherine.baker@northumbria.ac.uk
The study is sponsored by University of Northumbria at Newcastle and funded by MEDICAL RESEARCH FOUNDATION .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 52997
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