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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
David
Fawkner-Corbett
davidfc@doctors.org.uk
Paul
Johnson
paul.johnson@nds.ox.ac.uk
Other diseases of the digestive system
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
The intestinal barrier is a vitally important interface through which an individual will interact with the outside world. In early childhood a number of important events occur in the intestine - immune cells encounter bacteria for the first time, the intestine will be exposed to diet and digestion will begin. Problems with these processes can cause disease, but very little is known about what the normal process is. This is made more challenging due to the scarcity of tissue collected in this age group.
This project will seek to build on previous work undertaken by the team that has used methods to study the genetic expression of individual cells. This has characterised the intestine at unprecedented resolution in human development and adult inflammatory bowel disease to reveal causes of dysregulation, but placing normal events and disease processed in childhood has not been possible.
This study will seek to reveal new information about the intestine in early childhood development, by collecting samples including tissue, blood and stool from up to 250 children already having intestinal surgery for a range of conditions as part of their medical care. This will encompass different stages of maturity and disease contexts, along with a sub-group undergoing longitudinal sampling if having a future surgical procedure.
The samples will be studied with recently developed techniques that can map the features of each single cell and look at the interactions between cells, and link this with samples from the blood and stool to reveal new information on what constitutes normal maturation at this time, and how it changes in disease. It is hoped this information will identify the specific cell types involved in rare paediatric diseases, which can then be validated in already collected pathology samples, and could identify new ways to understand or treat these rare conditions.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Clinical Laboratory Study;
You can take part if:
You may not be able to take part if:
The participant may not enter the study if ANY of the following apply: • Participant or parents/carer is unable to give informed consent • Participant is suffering any severe haematological disease such as haemophilia or ongoing haemorrhage where repeated blood sampling may be detrimental to the patient’s health • Participant has previously had significant intestinal resection or a diagnosis of condition such as “short bowel syndrome” where clinician feels inclusion may affect the resection specimen negatively at time of resection. • Surgical procedure is so acute that the participant/parent may not have time to adequately consider inclusion to the study.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of Oxford and funded by Wellcome Trust .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 52212
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
