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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Steven
Williams
Steven.williams@ed.ac.uk
Neil
Bodagh
neil.bodagh@kcl.ac.uk
Dr
Steven
Williams
Steven.williams@ed.ac.uk
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Atrial fibrillation is a common condition causing an irregular heartbeat, breathlessness and tiredness. Atrial fibrillation
occurs owing to abnormalities in the electrical circuits controlling the upper heart chambers.
Atrial fibrillation can be treated with a keyhole procedure called ablation. During ablation small areas in the heart are
burnt away to stop the abnormal circuits causing atrial fibrillation. Unfortunately, ablation only works for 50-90% of
people. We are not sure why, but possibly because the electrical circuits responsible are different in every heart.
This research will examine how these electrical circuits can be identified and treated. A new system using computer
modelling will be developed to identify the electrical circuits present. In the future we hope this approach could be
used to design tailor-made treatments for each patient. A combination of computer studies and studies involving
patients will be used to test this new approach in this study.
For this study patients who are already planned to undergo an ablation procedure will be recruited providing data for
three Work Packages. Consent will be sought to access routine investigations and data for research purposes (e.g.
ECGs, blood tests, ambulatory monitoring, cardiac imaging, and outpatient clinical assessment)Íľ and collect extra
data for research including additional cardiac imaging, a 2-week heart monitor pre- and post-ablation, and extra
electrical measurements made during the ablation procedure.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
Any clinical contra-indication to ablation Any disease limiting life expectancy to < 1year Contra-indication to MRI including renal dysfunction (eGFR<30ml/min) Potential participant currently pregnant or breast feeding Prior ablation, cardiac surgery or presence of any prosthetic valves Myocardial infarction or PCI within 3 months preceding consent date Hypertrophic cardiomyopathy or other inherited cardiac condition Presence / likely implant of any pacemaker, cardiac resynchronisation therapy device or implantable defibrillator within 1 year Enrolment in an existing interventional atrial fibrillation study which alters treatment or follow-up Use of amiodarone for any indication within 6 months prior to the planned ablation period Use of any anti arrhythmic drug for an arrhythmia indication other than atrial fibrillation Prior documented typical cavotricuspid isthmus dependent right atrial flutter and planned cavotricuspid isthmus ablation to be performed at the time of atrial fibrillation ablation
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Neil
Bodagh
neil.bodagh@kcl.ac.uk
Dr
Steven
Williams
Steven.williams@ed.ac.uk
Dr
Steven
Williams
Steven.williams@ed.ac.uk
The study is sponsored by University of Edinburgh and funded by BRITISH HEART FOUNDATION .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 52032
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
