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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Greg
Elder
g.elder@northumbria.ac.uk
Dr
Greg
Elder
g.elder@northumbria.ac.uk
Other degenerative diseases of the nervous system
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Dementia with Lewy bodies (DLB) is the second most common form of dementia. Sleep problems are a common feature of DLB, and the best-understood sleep symptom in DLB is rapid eye movement (REM) behaviour disorder, where people appear to act out their dreams during REM sleep. However, we do not know much about what happens during non-REM sleep in people with DLB.
There are two relevant features of brain activity that occur during non-REM sleep; these are known as sleep spindles and slow-wave sleep. These features of sleep originate from parts of the brain that are affected by DLB. Additionally, these features of sleep are very strongly associated with attention, learning and memory, which is impaired in people with DLB.
In this study, we will measure brain activity during sleep in people with DLB, Alzheimer’s dementia (AD) and people without dementia, using a non-invasive technique called polysomnography. We will examine if these features of non-REM sleep are different in DLB and AD, and if they are associated with learning and memory in DLB.
We expect that sleep spindles and slow-wave sleep will be different in DLB. This might help us to use home-based sleep monitoring to improve the diagnosis of DLB.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
Participants cannot take part if they have the following: Exclusion criteria will include a history of head injury, stroke, cerebrovascular disease/epilepsy, alterations to medication in the previous month, or sedative/hypnotic medication with the potential to affect sleep spindles (e.g. high doses of melatonin/benzodiazepines). Psychotropic and other medications which may significantly interfere with cognitive & TMS-EEG testing (including but not limited to antipsychotics, sedative antidepressants, benzodiazepines except low dose when used as hypnotics or treatment for REM-sleep behaviour disorder, and centrally acting anticholinergic drugs) • The presence of, or a history of, delirium. • A history of excess alcohol intake. • Presence of severe disease and significant physical co-morbidities
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by CUMBRIA, NORTHUMBERLAND, TYNE AND WEAR NHS FOUNDATION TRUST and funded by ALZHEIMER'S RESEARCH UK .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 51973
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