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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Ischaemic heart diseases
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40% of patients presenting with stable chest pain (angina) have no significant blockage of the main heart arteries. Identifying why these patients have symptoms will mean better treatment options can be developed. About 60% of these patients have evidence of coronary microvascular disease (CMD). In this condition there is a problem with the heart's microvessels (very small blood vessels that branch from the main heart arteries). Due to problems with these vessels there is a mismatch between the blood supply to the heart and its oxygen consumption, causing chest pain and this can also lead to major heart events. At present, to diagnose this condition, specialised techniques during an invasive test, called a coronary angiogram, are required. As this is an invasive test, it can be lead to complications and cause discomfort. Non-invasive ways of diagnosing CMD are required to improve the diagnosis and management of this condition.
This study aims to provide pilot data on whether novel imaging techniques using CT and MRI scans, which are much less invasive, could identify CMD. To do this, patients with suspected angina referred for angiography and who are already participants of the ‘CMR versus CT-FFR in CAD’ study will be recruited. These will be patients with suspected CMD and also those with blockage of the main heart arteries to compare against. Participants will have additional tests used to diagnose CMD during their invasive angiography procedure. Participants will then have an MRI scan involving novel techniques and exercise MRI, where individuals exercise use a cycle or stepping machine during the MRI scan. Further analysis will also be undertaken of CT images acquired as part of the ‘CMR versus CT-FFR in CAD’ study. These tests will be compared against invasive test results to see which show potential in being able to diagnose CMD.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Case-controlled study;
You can take part if:
You may not be able to take part if:
The same as the main study: • Recent acute coronary syndrome (< 6 months) • Severe claustrophobia • Absolute contraindications to CMR - those with MR conditional or safe devices will be included • Second-/third-degree atrioventricular block • Severe chronic obstructive pulmonary disease • Moderate-severe asthma • Estimated glomerular filtration rate < 30 ml/min/1.73m2 • Women who are pregnant, breast-feeding or of child-bearing potential (premenopausal women) • Contraindication to iodinated contrast • Participants who have participated in a research study involving an investigational product in the past 12 weeks • Patients unable to understand written English
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of Leicester and funded by BRITISH HEART FOUNDATION .
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Read full details
for Trial ID: CPMS 51904
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