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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Diseases of liverMalignant neoplasms of digestive organs
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Cirrhosis is a condition where the liver becomes scarred and loses function. It is an important and often under recognised condition, affecting over 300,000 patients across the North East and Cumbria. In patients who require surgery on their stomach or bowel, cirrhosis can be associated with high rates of death and complications and may become a barrier to patients accessing surgery. Currently we lack a reliable method of identifying which patients with cirrhosis are most at risk of death and other complications. This study sets out to develop a new method of establishing the risk of surgery in patients with cirrhosis.
An important complication cirrhosis is the development of high pressure in the veins that supply blood to the liver. Measuring the pressure in the liver blood vessels can predict the risk of complications after surgery. This study sets out to develop a series of tests that can be used to measure the pressure and calculate that risk. We will undertake this study in 30 patients with cirrhosis who need to have surgery to treat their bowel or stomach cancer. We will measure the pressure in the blood vessels supplying the liver and investigate what happens if they have surgery or if surgery is not safe. We will then use this data to design a larger, UK–based study to establish the risk of surgery in patients with cirrhosis and whether the degree of pressure corresponds with that risk. This study will enable surgeons to help patients with cirrhosis decide what is the best treatment if they develop cancer and potentially explore the role of strategies to modify pressure and improve their outcomes.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Qualitative;
You can take part if:
You may not be able to take part if:
- Patients under the age of 18 - who are unable to understand and speak English or lack capacity to consent - patients with decompensated cirrhosis (Child-Pugh score > 7) - patient with extrahepatic portal hypertension and patients with unresectable primary colorectal cancer - patients presenting as an emergency with complicated bowel pathology (obstruction, perforation) or metastatic colorectal cancer
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by THE NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST and funded by LIVERNORTH .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 51474
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
